Summary
Mirroring the ambiguities noted with other endocrine tumours, histology is a poor predictor of the invasiveness of pituitary adenomas. Accordingly, the proteins p27Kip 1 (p27) and Ki-67, which respectively block cell-cycle progression and reflect proliferative activity of cells, were studied immunohistochemically in 123 specimens of pituitary adenomas including 57 clinically verified invasive cases. Only Ki-67 had a significant association with invasiveness; only p27 differed significantly between functioning and nonfunctioning adenomas, with a higher frequency of cell labelling in the former. No relationship between Ki-67 and p27 was obtained. Ki-67 detected by MIB-1 is thus an important marker related to the invasive potential of adenomas, and thereby may be helpful in planning postoperative management of patients with pituitary adenomas.
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Zhao, D., Tomono, Y. & Nose, T. Expression of P27kip 1 and Ki-67 in Pituitary Adenomas: An Investigation of Marker of Adenoma Invasiveness. Acta Neurochir (Wien) 141, 187–192 (1999). https://doi.org/10.1007/s007010050285
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DOI: https://doi.org/10.1007/s007010050285