Abstract
Purpose
To evaluate the effectiveness of using soft coagulation followed by the application of polyglycolic acid (PGA) felt and fibrin glue to prevent pancreatic fistula (PF) after distal pancreatectomy (DP).
Methods
A soft coagulation system was applied on the cut surface of the pancreas after ligating the main pancreatic duct, followed by the application of layers of PGA felt and fibrin glue on the layers, to prevent the development of a PF after DP.
Results
This technique was applied in nine patients, with mean drain amylase levels of 372 ± 296, 185 ± 209, 54 ± 40, and 47 ± 34 IU/l on days 1, 3, 5, and 7, respectively, after DP. Only one patient (11.1%) showed a Grade A PF on day 3 after surgery; none of the other patients developed a fistula.
Conclusions
This technique is an effective prophylactic measure to prevent the development of a PF after DP.
Similar content being viewed by others
References
Vin Y, Sima CS, Getrajdman GI, Brown KT, Covey A, Brennan MF, et al. Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg 2008;207:490–498.
Sledzianowski JF, Duffas JP, Muscari F, Suc B, Fourtanier F. Risk factors for mortality and intra-abdominal morbidity after distal pancreatectomy. Surgery 2005;137:180–185.
Sahm M, Pross M, Schubert D, Lippert H. Laparoscopic distal pancreatic resection: our own experience in the treatment of solid tumors. Surg Today 2009;39:1103–1108.
Butturini G, Daskalaki D, Molinari E, Scopelliti F, Casarotto A, Bassi C. Pancreatic fistula: definition and current problems. J Hepatobiliary Pancreat Surg 2008;15:247–251.
Nagakawa Y, Tsuchida A, Saito H, Tohyama Y, Matsudo T, Kawakita H, et al. The VIO soft-coagulation system can prevent pancreatic fistula following pancreatectomy. J Hepatobiliary Pancreat Surg 2008;15:359–365.
Hirokawa F, Hayashi M, Miyamoto Y, Iwamoto M, Tsunematsu I, Asakuma M, et al. A novel method using the VIO soft-coagulation system for liver resection. Surgery 2011;149:438–444.
Ochiai T, Sonoyama T, Soga K, Inoue K, Ikoma H, Shiozaki A, et al. Application of polyethylene glycolic acid felt with fibrin sealant to prevent postoperative pancreatic fistula in pancreatic surgery. J Gastrointest Surg 2010;14:884–890.
Golling M, Schaudt A, Mehrabi A, Mood ZA, Bechstein WO. Clinical application of soft polyglycolic acid felt for hemostasis and repair of a lacerated liver: report of two cases. Surg Today 2008;38:188–192.
Itano H. The optimal technique for combined application of fibrin sealant and bioabsorbable felt against alveolar air leakage. Eur J Cardiothorac Surg 2008;33:457–460.
Strasberg SM, Linehan DC, Hawkins WG. Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins. J Am Coll Surg 2007;204:244–249.
Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005;138:8–13.
Kleeff J, Diener MK, Z’graggen K, Hinz U, Wagner M, Bachmann J, et al.Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases. Ann Surg 2007;245:573–582.
Abe N, Sugiyama M, Suzuki Y, Yamaguchi T, Mori T, Atomi Y. Preoperative endoscopic pancreatic stenting: a novel prophylactic measure against pancreatic fistula after distal pancreatectomy. J Hepatobiliary Pancreat Surg 2008;15:373–376.
Yoshioka R, Saiura A, Koga R, Seki M, Kishi Y, Morimura R, et al. Risk factors for clinical pancreatic fistula after distal pancreatectomy: analysis of consecutive 100 patients. World J Surg 2010;34:121–125.
Oláh A, Issekutz A, Belágyi T, HajdÚ N, Romics L Jr. Randomized clinical trial of techniques for closure of the pancreatic remnant following distal pancreatectomy. Br J Surg 2009;96:602–607.
Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, et al. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 2008;12:1691–1697.
Ohwada S, Ogawa T, Tanahashi Y, Nakamura S, Takeyoshi I, Ohya T, et al. Fibrin glue sandwich prevents pancreatic fistula following distal pancreatectomy. World J Surg 1998;22:494–498.
Hayashibe A, Sakamoto K, Shinbo M, Makimoto S, Nakamoto T. New method for prevention of bile leakage after hepatic resection. J Surg Oncol 2006;94:57–60.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ikegami, T., Maeda, T., Kayashima, H. et al. Soft coagulation, polyglycolic acid felt, and fibrin glue for prevention of pancreatic fistula after distal pancreatectomy. Surg Today 41, 1224–1227 (2011). https://doi.org/10.1007/s00595-010-4433-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00595-010-4433-7