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Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI

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Abstract

Purpose

The imaging discrimination between neurofibroma (NF) and malignant peripheral nerve sheath tumor (MPNST) is clinically very important. The purpose of this study is to define the criteria for the differential diagnosis between NF and MPNST on MRI in neurofibromatosis 1 (NF1).

Methods

A total of 37 patients with NF1, 18 NFs and 19 MPNSTs were evaluated by MRI at 1.5 T. Magnetic resonance imaging (MRI) findings were compared using univariate and multivariate analyses.

Results

The MRI findings characteristic of MPNST (p < 0.05) were an irregular tumor shape (15/19 in MPNST vs. 5/18 in NF), unclear margin (13/19 in MPNST vs. 6/18 in NF), intra-tumoral lobulation (12/19 in MPNST vs. 3/18 in NF), presence of high signal-intensity area on T1-weighted images (T1WI) (12/19 in MPNST vs. 1/18 in NF), no target sign (0/19 in MPNST vs. 12/18 in NF), inhomogeneous enhancement on contract-enhanced T1WI (17/18 in MPNST vs. 9/16 in NF) and a lower rate of enhanced area (54% in MPNST vs. 87% in NF) were critical indicators to differentiate MPNST from NF. A multivariate analysis showed that intra-tumoral lobulation and the presence of a high signal-intensity area on T1WI were considered to be diagnostic indicators of MPNST. The sensitivity and specificity for these two items were 63.2, 83.3, 63.2 and 87.5%, respectively.

Conclusion

MRI shows features which were helpful for differentiating MPNST from NF.

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Acknowledgments

We thank the secretarial staff (Chie Usui, Chiyuki Ueno and Mariko Tanaka) of the Department of Orthopedic Surgery, Mie University Graduate School of Medicine, for their generous cooperation. This work is supported in part by the grant from the Ministry of Health, Labour and Welfare (Grants-in Aid for Clinical Cancer Research).

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Correspondence to Akihiko Matsumine.

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Matsumine, A., Kusuzaki, K., Nakamura, T. et al. Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI. J Cancer Res Clin Oncol 135, 891–900 (2009). https://doi.org/10.1007/s00432-008-0523-y

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  • DOI: https://doi.org/10.1007/s00432-008-0523-y

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