Abstract
Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.
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Acknowledgements
This text presents research results of the Belgian program on Interuniversity Poles of Attraction initiated by the Belgian Sate, Prime Minister’s Office, Science Policy Programming. The authors of the text assume the scientific responsibility. The authors would like to acknowledge the Cooperation in Scientific and Technical Research (COST) support through the COST ACTION B19 “Molecular cytogenetics of solid tumors” in carrying out this work. The authors would like to thank Belinda Carleer and Venessa Vanspauwen for their excellent technical assistance.
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Maggiani, F., Debiec-Rychter, M., Verbeeck, G. et al. Extramammary myofibroblastoma is genetically related to spindle cell lipoma. Virchows Arch 449, 244–247 (2006). https://doi.org/10.1007/s00428-006-0228-z
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DOI: https://doi.org/10.1007/s00428-006-0228-z