Abstract
Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.
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References
Ali S, Teichberg S, DeRisi DC (1994) Giant myofibroblastoma of the male breast. Am J Surg Pathol 18:1170–1176
Chan K-W, Ghadially FN, Alagaratnam TT (1984) Benign Spindle cell tumor of the breast: a variant of spindle cell lipoma or fibroma of breast. Pathology 16:331–336
Dahlen A, Debiec-Rychter M, Pedeutour F, Domanski HA, Hoglund M, Bauer HC, Rydholm A, Sciot R, Mandahl N, Mertens F (2003) Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer 103:616–623
Dal Cin P, Sciot R, Polito P, Stas M (1997) Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas. Histopathology 31:222–225
Debiec-Rychter M, Lasota J, Sarlomo-Rikala M, Kordek R, Miettinen M (2001) Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation. Cancer Genet Cytogenet 128:24–30
Lee AH, Sworn MJ, Theaker JM (1993) Myofibroblastoma of breast: an immunohistochemical study. Histopathology 22:75–78
Magro G, Michal M, Bisceglia M (2001) Benign spindle cell tumors of the mammary stroma: diagnostic criteria, classification, and histogenesis. Pathol Res Pract 197:453–466
Magro G, Bisceglia M, Michal M, Eusebi V (2002) Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. Virchows Arch 440:249–260
McMenamin, Fletcher CD (2001) Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. Am J Surg Pathol 25:1022–1029
Nucci MR, Fletcher CD (1999) Myofibroblastoma of the breast: a distinctive benign stromal tumor. Pathol Case Rev 4:214–219
Pauwels P, Sciot R, Croiset F, Rutten H, Van den Berghe H, Dal Cin P (2001) Myofibroblastoma of the breast: genetic link with spindle cell lipoma. J Pathol 191:282–285
Toker C, Tang C-K, Whitely JF (1981) Benign spindle cell breast tumor. Cancer 48:1615–1622
Wargotz ES, Weiss SW, Norris HJ (1987) Myofibroblastoma of the breast: sixteen cases of a distinctive benign mesencymal tumor. Am J Surg Pathol 11:493–502
Acknowledgements
This text presents research results of the Belgian program on Interuniversity Poles of Attraction initiated by the Belgian Sate, Prime Minister’s Office, Science Policy Programming. The authors of the text assume the scientific responsibility. The authors would like to acknowledge the Cooperation in Scientific and Technical Research (COST) support through the COST ACTION B19 “Molecular cytogenetics of solid tumors” in carrying out this work. The authors would like to thank Belinda Carleer and Venessa Vanspauwen for their excellent technical assistance.
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Maggiani, F., Debiec-Rychter, M., Verbeeck, G. et al. Extramammary myofibroblastoma is genetically related to spindle cell lipoma. Virchows Arch 449, 244–247 (2006). https://doi.org/10.1007/s00428-006-0228-z
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DOI: https://doi.org/10.1007/s00428-006-0228-z