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Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients

  • Controlled Clinical Trial
  • Published:
Langenbeck's Archives of Surgery Aims and scope Submit manuscript

Abstract

Background

Postoperative weight loss and malnutrition are major issues in gastric cancer patients. The concept of oral nutritional supplements (ONS) is gaining widespread acceptance. We investigated the effects of ONS administration on postoperative body weight loss in patients with gastric cancer who had undergone total gastrectomy or distal gastrectomy.

Methods

Patients were randomized to either the treatment or the control group. In both groups, standard surgery for gastric cancer was performed. In the treatment group, intervention with ONS was performed until 12 weeks after discharge. In the control group, patients were fed the usual postoperative diet. Weight, body composition, quality of life, hematological parameters, and blood chemistry were evaluated.

Results

We analyzed 113 cases (73 distal gastrectomy, 40 total gastrectomy). Weight loss in the ONS group after total gastrectomy was significantly less than that in the control group. Weight loss and skeletal muscle mass loss after distal gastrectomy did not differ significantly between the ONS and control groups.

Conclusion

This study showed ONS after total gastrectomy to significantly diminish postoperative weight loss.

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Acknowledgments

The authors thank all of the physicians, dietitians, nurses, and patients whose cooperation made this study possible.

Authors’ contributions

Study conception and design: Yasuyuki Seto, Ming-Tsan Lin, Kazuhiko Fukatsu

Acquisition of data: Fumihiko Hatao, Kuen-Yuan Chen, Jin-Ming Wu, Ming-Yang Wang, Haruna Onoyama, Nobuyuki Shimizu

Analysis and interpretation of data: Fumihiko Hatao, Kuen-Yuan Chen, Jin-Ming Wu, Susumu Aikou

Drafting of manuscript: Fumihiko Hatao , Kuen-Yuan Chen

Critical revision of manuscript: Yasuyuki Seto, Ming-Tsan Lin

Author information

Authors and Affiliations

  1. Department of Surgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan

    Fumihiko Hatao

  2. Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan

    Kuen-Yuan Chen, Jin-Ming Wu, Ming-Yang Wang & Ming-Tsan Lin

  3. Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan

    Susumu Aikou, Haruna Onoyama, Nobuyuki Shimizu & Yasuyuki Seto

  4. Surgical Center, The University of Tokyo Hospital, Tokyo, Japan

    Kazuhiko Fukatsu

Authors
  1. Fumihiko Hatao
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  2. Kuen-Yuan Chen
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  3. Jin-Ming Wu
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  4. Ming-Yang Wang
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  6. Haruna Onoyama
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  7. Nobuyuki Shimizu
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  8. Kazuhiko Fukatsu
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  9. Yasuyuki Seto
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  10. Ming-Tsan Lin
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Corresponding author

Correspondence to Yasuyuki Seto.

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Funding

This study received financial support from the EN Otsuka Pharmaceutical Co., Ltd.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants whose data are included in the study.

Additional information

Fumihiko Hatao and Kuen-Yuan Chen contributed equally to this work as first authors.

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Hatao, F., Chen, KY., Wu, JM. et al. Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients. Langenbecks Arch Surg 402, 203–211 (2017). https://doi.org/10.1007/s00423-016-1527-8

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  • DOI: https://doi.org/10.1007/s00423-016-1527-8

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