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IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort

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Abstract

Background

Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also well documented.

Methods

Gene promoter polymorphisms in IL-10 (−1082 G>A and −819 C>T) was analyzed in 159 PCa patients and 259 healthy controls to investigate their potential association with susceptibility for PCa.

Results

Our results indicated that the heterozygous (GA) and homozygous mutant (AA) genotypes of IL-10 −1082 to be more prevalent among PCa patients in comparison to controls (GA: OR − 2.8, p = 0.011; AA: OR − 2.3, p = 0.037). More patients (92.5%) than controls (82.7%) were positive for the A allele (GA + AA: OR − 2.6, p = 0.015). We observed lower frequency of T(−819)-G(−1082) haplotype in patients without bone metastasis (4.4%, OR − 0.30, p = 0.019) in comparison to PCa patients with bone metastasis (12.6%).

Conclusion

Our results support the emerging hypothesis that genetically determined immune activity may play a role in the pathophysiology of PCa. Our findings of high producer of IL-10 −1082 variants suggest initiation of PCa. Future studies in large cohort of different ethnicity PCa groups are warranted to establish definite associations with other cytokine gene polymorphisms.

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Acknowledgments

The work was supported by Department of Science and Technology, New Delhi. The authors are thankful to Dr. Anil Mandhani (Department Of Urology) and senior residents of Department of Urology for recruitment of patients and organising health check-up camps from time to time which was helpful in collecting healthy controls. PK is thankful to Indian Council of Medical Research, New Delhi and DKA is thankful to Department of Biotechnology, New Delhi, for Senior Research Fellowship.

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There is no conflict of interest.

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Authors and Affiliations

  1. Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, 226014, India

    Pravin Kesarwani, Dinesh Kumar Ahirwar, Anil Mandhani & Rama D. Mittal

  2. Department of Urology, CSJ Medical University, Lucknow, Uttar Pradesh, India

    Anand Narayan Singh & Divakar Dalela

  3. Department of Pathology, CSJ Medical University, Lucknow, Uttar Pradesh, India

    Anand Narain Srivastava

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  1. Pravin Kesarwani
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  2. Dinesh Kumar Ahirwar
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  3. Anil Mandhani
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  4. Anand Narayan Singh
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  5. Divakar Dalela
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  6. Anand Narain Srivastava
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  7. Rama D. Mittal
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Correspondence to Rama D. Mittal.

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Kesarwani, P., Ahirwar, D.K., Mandhani, A. et al. IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort. World J Urol 27, 389–396 (2009). https://doi.org/10.1007/s00345-008-0361-1

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  • DOI: https://doi.org/10.1007/s00345-008-0361-1

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