Abstract
Purpose
To evaluate differences in apparent diffusion coefficient (ADC) values for the solid component of benign and malignant ovarian surface epithelial tumors with the goal of differentiating benign versus malignant ovarian tumors preoperatively.
Materials and methods
A total of 127 patients with 131 pelvic masses identified by ultrasound between January 2006 and January 2011 were enrolled in this study. 46 patients were diagnosed with benign tumors, and 85 patients were diagnosed with malignant pathologies. For all of the patients, routine spin-echo MRI and diffusion-weighted imaging were performed. ADC values were determined for all of the masses, and the mean ADC values for the benign and malignant tumors were analyzed using Student’s t test. A P value <0.05 was considered statistically significant.
Results
Mean ADC values associated with malignant ovarian surface epithelial tumors were significantly lower than the mean ADC values of the benign tumors. In addition, the range of ADC values associated with a 95% confidence interval did not overlap between the two groups. ROC analysis indicated that a cutoff ADC value of 1.25 × 10−3 mm2/s was associated with 90.1% sensitivity and 89.9% specificity.
Conclusion
ADC values determined from 1.5 T MR DWI of benign and malignant ovarian masses were found to be significantly different.
Similar content being viewed by others
References
Sutton CL, McKinney CD, Jones JE, Gay SB (1992) Ovarian masses revisited: radiologic and pathologic correlation. Radiographics 12:853–877
Bazot M, Darai E, Nassar-Slaba J, Lafont C, Thomassin-Naggara I (2008) Value of magnetic resonance imaging for the diagnosis of ovarian tumors: a review. J Comput Assist Tomogr 32:712–723
Sohaib SAA, Sahdev A, Trappen PV, Jacobs IJ, Reznek RH (2003) Characterization of adnexal mass lesions on MR imaging. AJR 180:1297–1304
Ghossain MA, Buy JN, Ligneres C, et al. (1991) Epithelial tumors of the ovary: comparison of MR and CT findings. Radiology 181:863–870
Jung SE, Lee JM, Rha SE, et al. (2002) CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics 22:1305–1325
Katayama M, Masui T, Kobayashi S, et al. (2002) Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients? J Comput Assist Tomogr 26:250–256
Timmerman D, Valentin L, Bourne TH, et al. (2000) Terms, definitions and measurements to describe the sonographic features of adenexal tumors: a consensus opinion from the International Ovarian Tumor Analysis(IOTA) Group. Ultrasound Obstet Gynecol 16:500–505
Thomassin-Naggara I, Darai E, Cuenod CA, et al. (2008) Dynamic contrast-enhanced magnetic resonance imaging: a useful tool for characterizing ovarian epithelial tumors. J Magn Reson Imag 28:111–120
Moteki T, Ishizaka H (1998) Evaluation of cystic ovarian lesions using apparent diffusion coefficient from turboFLASH MR images. Br J Radiol 71:612–620
Kim KA, Park CM, Lee JH, et al. (2004) Benign ovarian tumors with solid and cystic components that mimic malignancy. AJR 182:1259–1265
Thomassin-Naggara I, Darai E, Cuenod CA, et al. (2009) Contribution of diffusion-weighted MR imaging for predicting benignity of complex adnexal masses. Eur Radiol 19:1544–1552
Bazot M, Nassar-Slaba J, Thomassin-Naggara I, et al. (2006) MR imaging compared with intraoperative frozen-section examination for diagnosis of adnexal tumors; correlation with final histology. Eur Radiol 16:2687–2699
Umemoto M, Shiota M, Shimono T, et al. (2006) Preoperative diagnosis of ovarian tumors, focusing on the solid area based on diagnostic imaging. J Obstet Gynaecol Res 32:195–201
Thomassin-Naggara I, Toussaint I, Perrot N, et al. (2011) Characterization of complex adnexal masses: value of adding perfusion-and diffusion-weighted MR imaging to conventional MR imaging. Radiology 258:793–803
Erturk SM, Ichikawa T, Sano K, et al. (2008) Diffusion-weighted magnetic resonance imaging for characterization of focal liver masses: impact of parallel imaging (SENSE) and b value. J Comput Assist Tomogr 32:865–871
Nakai G, Matsuki M, Inada Y, et al. (2008) Detection and evaluation of pelvic lymph nodes in patients with gynecologic malignancies using body diffusion-weighted magnetic resonance imaging. J Comput Assist Tomogr 32:764–768
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, W., Chu, C., Cui, Y. et al. Diffusion-weighted MRI: a useful technique to discriminate benign versus malignant ovarian surface epithelial tumors with solid and cystic components. Abdom Radiol 37, 897–903 (2012). https://doi.org/10.1007/s00261-011-9814-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00261-011-9814-x