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The multiple facets of periostin in bone metabolism

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Abstract

Periostin is a matricellular glutamate-containing protein expressed during ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator of bone formation. The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases.

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Abbreviations

βig-H3 protein:

transforming growth factor-β-inducible protein

BMP:

bone morphogenetic protein

CRS:

carboxylase recognition sites

dpc:

days postconception

DPD:

deoxypyridinoline

DHLNL:

dihydroxylysinonorleucine

ECM:

extracellular matrix

FAK:

focal adhesion kinase

FGF:

basic fibroblast growth factors

Gla:

γ-carboxyglutamate

Glu:

glutamate

HLNL:

hydroxylysinonorleucine

LOX:

lysyl oxidase

PDL:

periodontal ligament

PDGF:

platelet-derived growth factor

PHPT:

primary hyperparathyroidism

PLF:

periostin-like factor

PTH:

parathyroid hormone

PTHrP:

parathyroid hormone-related peptide

PYD:

pyridinoline

TNFα:

tumor necrosis factor α

TRAP5b:

tartrate resistant acid phosphatase

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Acknowledgements

The authors would like to thank Dr. Sylvain Contie for helpful discussion on this manuscript.

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Merle, B., Garnero, P. The multiple facets of periostin in bone metabolism. Osteoporos Int 23, 1199–1212 (2012). https://doi.org/10.1007/s00198-011-1892-7

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  • DOI: https://doi.org/10.1007/s00198-011-1892-7

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