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Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

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Abstract

Osteocalcin is a hormone secreted by osteoblasts, which regulates energy metabolism by increasing β-cell proliferation, insulin secretion, insulin sensitivity, and energy expenditure. This has been demonstrated in mice, but to date, the evidence implicating osteocalcin in the regulation of energy metabolism in humans are indirect. To address this question more directly, we asked whether a benign osteoblastic tumor, such as osteoma osteoid in young adults, may secrete osteocalcin. The study was designed to assess the effect of surgical resection of osteoid osteoma on osteocalcin and blood glucose levels in comparison with patients undergoing knee surgery and healthy volunteers. Blood collections were performed the day of surgery and the following morning after overnight fasting. Patients and controls were recruited in the orthopedic surgery department of New York Presbiterian Hospital, NY-USA and Hospices Civils de Lyon, France. Seven young males were included in the study: two had osteoid osteoma, two underwent knee surgery, and three were healthy volunteers. After resection of the osteoid osteomas, we observed a decrease of osteocalcin by 62% and 30% from the initial levels. Simultaneously, blood glucose increased respectively by 32% and 15%. Bone turnover markers were not affected. This case study shows for the first time that osteocalcin in humans affects blood glucose level. This study also suggests that ostoid osteoma may be considered, at least in part, as an osteocalcinoma.

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Acknowledgments

The authors acknowledge Patricia Ducy, Jacques Bejui-Hugues, Jean-Paul Carret, Vincent Pibarot, Damien Pourre, Philippe Bovier-Lapierre, Simone Arnaud, Laurence Chardon, Pawel Szulc, Franck Chotel, and Rémi Kohler for their help.

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None.

Author information

Authors and Affiliations

  1. Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    C. B. Confavreux & G. Karsenty

  2. Department of Rheumatology, Hospices Civils de Lyon, INSERM UMR 1033, Université de Lyon, Pavillon F, 5 place d’Arsonval, 69003, Lyon, France

    C. B. Confavreux, O. Borel, C. Fadat & R. Chapurlat

  3. Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    F. Lee

  4. Department of Orthopedic Surgery, Hospices Civils de Lyon, Université de Lyon, 69003, Lyon, France

    G. Vaz & M. Guyard

  5. Hospices Civils de Lyon, Fédération de Biochimie, Groupement Hospitalier Sud, 69495, Pierre Bénite, France

    M.-C. Carlier

Authors
  1. C. B. Confavreux
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  2. O. Borel
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  3. F. Lee
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  4. G. Vaz
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  5. M. Guyard
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  6. C. Fadat
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  7. M.-C. Carlier
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  8. R. Chapurlat
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  9. G. Karsenty
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Corresponding author

Correspondence to C. B. Confavreux.

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Funding sources

This work was supported by grants from Philippe Foundation Inc, Société Française de Rhumatologie (SFR), and Association pour la Recherche sur le Cancer (ARC) to C.B. Confavreux.

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Confavreux, C.B., Borel, O., Lee, F. et al. Osteoid osteoma is an osteocalcinoma affecting glucose metabolism. Osteoporos Int 23, 1645–1650 (2012). https://doi.org/10.1007/s00198-011-1684-0

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  • DOI: https://doi.org/10.1007/s00198-011-1684-0

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