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Helicobacter pylori gastritis—Epidemiology

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Abstract

The acquisition ofHelicobacter pylori is the main cause of chronic gastritis in humans. In Europe, a small proportion (less than 1%) of gastritis cases are caused byH. Heilmannii, and somewhat more (5%) are autoimmune in origin, in which conditionH. pylori may not probably play a role. Recent findings on chronic gastritis andH. pylori acquisition in developed countries can be summarized as: (1)H. pylori gastritis is acquired in childhood and adolescence (age less than 20) in more than 50% of cases; (2) the risk and rate of acquisition is highest in early childhood, after which the rate exponentially declines; (3) new infectious occur in adulthood but are quite rare (annual incidence 0.4%, on average, in Finland); (4)H. pylori gastritis is a birth cohort-related phenomenon; i.e., different cohorts show a rate and prevalence ofH. pylori gastritis that varies between cohorts; (5) the rate and risk ofH. pylori infection is high in cohorts born in the beginning of the century, but is much lower in those born later; (6) this decline is due to a decrease in the rate and risk ofH. pylori acquisition in childhood in particular.H. pylori gastritis—related complications, such as peptic ulcer diseases and gastric cancer, show epidemiological features similar toH. pylori gastritis. Both peptic ulcer and gastric cancer have declined in incidence over time. Gastric cancer is a birth-cohort phenomenon in the same way as isH. pylori gastritis, and the incidence of gastric cancer shows a positive but exponential relationship with the “birth-cohort-specific” prevalence of gastritis in the general population.

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References

  1. Price AB. The Sydney System: Histological division. J Gastroenterol Hepatol 1991;6:209–222.

    Article  PubMed  CAS  Google Scholar 

  2. Whitehead R, Truelove SC, Gear MW. The histological diagnosis of chronic gastritis in fibreoptic biopsy specimens. J Clin Pathol 1972;25:1–11.

    Article  PubMed  CAS  Google Scholar 

  3. Siurala M, Sipponen P, Kekki M. Chronic gastritis: Dynamic and clinical aspects. Scand J Gastroenterol 1985;20(Suppl 109): 69–76.

    Article  Google Scholar 

  4. Valle H, Kekki M, Sipponen P, Siurala M. The natural history ofH. pylori gastritis: A 30-year histologic follow-up study. VIIIth International workshop on gastroduodenal pathology andHelicobacter pylori. Edinburgh, July 7–9, 1995.

  5. Kuipers EJ, Pena AS, Kamp Van G, et al. Seroconversion ofHelicobacter pylori. Lancet 1993;342:328–331.

    Article  PubMed  CAS  Google Scholar 

  6. Sipponen P, Kekki M, Siurala M. The Sydney System: Epidemiology and natural history of chronic gastritis. J Gastroenterol Hepatol 1991;6:244–251.

    Article  PubMed  CAS  Google Scholar 

  7. Kekki M, Varis K, Pohjanpanpalo H, et al. Course of antrum and body gastritis in pernicious anemia families. Dig Dis Sci 1983;28:698–704.

    Article  PubMed  CAS  Google Scholar 

  8. Ihamäki T, Kekki M, Sipponen P, et al. The sequelae and course of chronic gastritis during a 30- to 40-year bioptic follow-up study. Scand J Gastroenterol 1985;20:485–491.

    Article  PubMed  Google Scholar 

  9. Siurala M, Sipponen P, Kekki M.Campylobacter pylori in a sample of Finnish population: Relations to morphology and functions of the gastric mucosa. Gut 1988;29:909–916.

    Article  PubMed  CAS  Google Scholar 

  10. Correa P. Chronic gastritis. In: Whitehead R (ed) Gastrointestinal and oesophageal pathology. Edinburgh: Churchill Livingstone, 1989:402–420.

    Google Scholar 

  11. Kekki M, Siurala M, Varis K, et al. Classification principles and genetics of chronic gastritis. Scand J Gastroenterol 1987;22(Suppl 141): 1–28.

    Google Scholar 

  12. Bonney G, Elston E, Correa P, et al. Genetic etiology of gastric carcinoma. I. Chronic gastritis. Genetic Epidemiol 1986;3:213–224.

    Article  CAS  Google Scholar 

  13. Lee A, Dixon M, Danon SJ, et al. Local acid production andHelicobacter pylori: A unifying hypothesis of gastroduodenal disease. Eur J Gastroenterol Hepatol 1995;7:461–465.

    PubMed  CAS  Google Scholar 

  14. Sipponen P, Hyvärinen H, Siurala M.H. pylori corpus gastritis— relation to acid output. J Physiol Pharmacol 1996;47:151–159.

    PubMed  CAS  Google Scholar 

  15. Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy 1969;1:87–97.

    Article  Google Scholar 

  16. Kimura K. Chronological transition of the fundic pyloric border determined by stepwise biopsy of the lesser and greater curvature of the stomach. Gastroenterology 1972;63:584–592.

    PubMed  CAS  Google Scholar 

  17. Banatvala N, Mayo K, Megraud F, et al. The cohort effect andHelicobacter pylori. J Infect Dis 1993;168:219–221.

    PubMed  CAS  Google Scholar 

  18. Parsonnet J, Blaser MJ, Perez-perez GI, et al. Symptoms and risk factors forHelicobacter pylori in a cohort of epidemiologists. Gastroenterology 1992;102:41–46.

    PubMed  CAS  Google Scholar 

  19. Cullen DJ, Collins BK, Cullen KJ, et al. A 21-year follow-up ofHelicobacter pylori infection—the cohort theory proven. Gut 1993;33:S4.

    Google Scholar 

  20. Sipponen P, Helske T, Järvinen P, et al. Fall in the prevalence of chronic gastritis over 15 years; analysis of outpatients series in Finland from 1977, 1985, and 1992. Gut 1994;35:1167–1171.

    Article  PubMed  CAS  Google Scholar 

  21. Kuipers EJ, Pena AS, Kamp Van G, et al. Seroconversion forHelicobacter pylori. Lancet 1993;342:328–331.

    Article  PubMed  CAS  Google Scholar 

  22. Mendall MA, Goggin PM, Molineaux N, et al. Childhood living conditions andHelicobacter pylori seropositivity in adult life. Lancet 1992;339:896–897.

    Article  PubMed  CAS  Google Scholar 

  23. Jones DM, Eldridge J, Whorwell PJ. Antibodies toCampylobacter pyloridis in household contacts of infected people. BMJ 1987;294:615.

    PubMed  CAS  Google Scholar 

  24. Hazell SL, Mitchell HM, Hu PJ, et al. Gastric cancer—is childhood acquisition ofH. pylori the key? Iris J Med Sci 1992;161: 22.

    Google Scholar 

  25. Megraud F, Brassens-Rabbe M-P, Denis F, et al. Seroepidemiology ofCampylobacter pylori infection in various populations. J Clin Microbiol 1989;27:1870–1873.

    PubMed  CAS  Google Scholar 

  26. Graham DY.Helicobacter pylori: Its epidemiology and its role in duodenal ulcer disease. J Gastroenterol Hepatol 1991;6:105–113.

    Article  PubMed  CAS  Google Scholar 

  27. Sipponen P, Seppälä K. Long-term consequences ofH. pylori infection: Time trends inH. pylori gastritis, gastric cancer and peptic ulcer disease. In: Hunt RH, Tytgat GNJ (eds)Helicobacter pylori. Basic mechanisms to clinical cure. Dordrecht: Kluwer Academic, 1994:372–380.

    Google Scholar 

  28. Pounder RE, Ng D. The prevalence ofHelicobacter pylori infection in different coutries. Aliment Pharmacol Ther 1995;9(Suppl 2): 33–39.

    PubMed  Google Scholar 

  29. Howson CP, Hiyama T, Wynder EL. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidem Rev 1986;8:1–27.

    CAS  Google Scholar 

  30. Coggon D, Acheson ED. The geography of cancer of the stomach. Br Med Bull 1984;40:335–341.

    PubMed  CAS  Google Scholar 

  31. Hakulinen T, Andersen AA, Malker B, et al. Trends in cancer incidence in the nordic countries. A collaborative study of the five nordic cancer registries. Acta Pathol Microbiol Immunol Scand (Sect A) 1986;94(Suppl 288):1–151.

    Google Scholar 

  32. Sonnenberg A. Temporal trends and geographical variations of peptic ulcer disease. Aliment Pharmacol Ther 1995;9(Suppl 2):3–21.

    PubMed  Google Scholar 

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Sipponen, P. Helicobacter pylori gastritis—Epidemiology. J Gastroenterol 32, 273–277 (1997). https://doi.org/10.1007/BF02936382

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