Summary
In experiments on cats cough reflexes were elicited by mechanical stimuli applied to the mucosa of the tracheobronchial tree. Narcotine was found to diminish or to depress the cough reflex in doses of 0.1–1.0 mg/kg and was thus about as effective as codeine. On the bronchial muscles narcotine produced no effect or a bronchodilatation whereas codeine produced a bronchoconstrictor effect. As an isochinoline derivative narcotine should not be liable to cause addiction.
This is a preview of subscription content, log in via an institution to check access.
Literatur
R. Meissner, Biochem. Z.54, 395 (1913).
K. van Dongen, Arch. internat. Pharmacodyn.64, 494 (1940).
R. Meissner, Biochem. Z.54, 395 (1913).
O. Hirz, Arch. exp. Pathol. Pharmakol.74, 318 (1913).
R. Domenjoz, Arch. exp. Pathol. Pharmakol.215, 19 (1952).
J. J. Toner undE. Macko, J. Pharmacol. exp. Therap.106, 246 (1952).
A. J. May undJ. G. Widdicombe, Brit. J. Pharmacol.9, 335 (1954).
H. Konzett undR. Rössler, Arch. exp. Pathol. Pharmakol.195, 71 (1940).
H. A. Bickerman undA. L. Barach, Amer. J. Med. Sci.228, 156 (1954).
Während der Drucklegung dieser Mitteilung wurden wir auf eine im J. Pharmacol. exp. Therap.112, 99 (1954) eben erschienene Untersuchung vonCh. A. Winter undL. Flataker aufmerksam, die Narkotin an Meerschweinchen und Hunden ungefähr gleich hustenhemmend wirksam fanden wie Codein.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Konzett, H., Rothlin, E. Zur Wirkung von Narkotin auf den Hustenreflex und auf die Bronchialmuskulatur. Experientia 10, 472–473 (1954). https://doi.org/10.1007/BF02170409
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02170409