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Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. I. Role of FcγRI cross-linking stimulation

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Abstract

This study demonstrates that immunodepressed trauma patients' monocytes produce elevated interleukin-6 to adherence, bacterial, and cytokine stimulation compared to immunocompetent trauma patients' or normals' monocytes, suggesting theirin vivo preactivation possibly mediated by the hyperimmunoglobulinemia which characterizes these patients. Furthermore, stimulation of monocytes through cross-linking their FcγRI induces and augments interleukin-6 (IL-6) production to subsequent stimulation both in trauma patients' (P<0.001) and in normals' (P<0.001) monocytes. As we reported earlier, immunodepressed trauma patients have an increased proportion of FcγRI-bearing monocytes in their total monocyte population and here we show that those FcγRI+ monocytes produce significantly elevated interleukin-6, suggesting a relationship between elevated monocyte interleukin-6 production and FcγRI triggering. Interleukin-6 induction by FcRI stimulation is not mediated solely by FcRI-induced MØ tumor necrosis factor alpha, IL-1α, or IL-1β production and is independent of MØ prostaglandin E2 levels. Therefore, FcRI stimulation-induced elevated MØ IL-6 might contribute to the increased immunoglobulin levels posttrauma.

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Szabo, G., Kodys, K. & Miller-Graziano, C.L. Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. I. Role of FcγRI cross-linking stimulation. J Clin Immunol 11, 326–335 (1991). https://doi.org/10.1007/BF00918798

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