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A randomized trial of intrahepatic arterial infusion of 4′-epidoxorubicin with Lipiodol versus 4′-epidoxorubicin alone in the treatment of hepatocellular carcinoma

  • Clinical Aspects in the Treatment for Operable and Session II. Chemotherapy and Radiotherapy II. 3. Reservoir and Others
  • Hepatocellular Carcinoma, Chemotherapy, Liiodol
  • Published:
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Abstract

We conducted a prospective randomized trial to evaluate the efficacy of Lipiodol in intrahepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma (HCC). A total of 38 patients with unresectable HCCs and underlying cirrhosis were entered in this trial, and 36 of them were evaluable. Every 4 weeks, 17 patients received 70 mg of 4′-epidoxorubicin (epirubicin) alone (group A), whereas 19 patients received a Lipiodol emulsion containing the same dose of epirubicin (group B) through the hepatic artery. A tumor response (CR+PR) was observed in 12% of group A patients and in 42% of group B patients. The group B patients showed a significantly higher response rate than the group A patients. There was a tendency for an increased duration of survival (P=0.09) in the group B patients. These results suggested that the infusion of the Lipiodol emulsion with epirubicin was more effective than epirubicin alone for the treatment of these patients with HCC.

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Authors and Affiliations

  1. Division of Internal Medicine, Juntendo University Urayasu Hospital, Urayasu, Japan

    Toshihiko Iijima & Masaji Nambu

  2. Division of Internal Medicine, Chiba Rosai Hospital, Chiba, Japan

    Shosuke Iwama

  3. Department of Surgery, Matsudo Municipal Hospital, Matsudo, Japan

    Fumio Endo

  4. Division of Internal Medicine, Chiba Kaihin Municipal Hospital, Chiba, Japan

    Michio Kimura

  5. Department of Surgery, Chiba West Hospital, Chiba, Japan

    Yoshiyuki Shimamura

  6. Division of Internal Medicine, Funabashi Municipal Medical Center, Funabashi, Japan

    Yasutoshi Suzuki

  7. Division of Internal Medicine, Social Insurance Funabashi Central Hospital, Funabashi, Japan

    Toshihiko Nakano

  8. Division of Internal Medicine, Kimitsu Central Hospital, Kimitsu, Japan

    Yoshio Fukuyama

  9. Department of General Internal Medicine, Jikei University, School of Medicine, Tokyo, Japan

    Kiyotaka Fujise

  10. First Department of Medicine, Chiba University, School of Medicine, 1-8-1 Inohana, Chuo-ku, 260, Chibashi, Chiba, Japan

    Masaharu Yoshikawa, Hiromitsu Saisho, Masaaki Ebara & Masao Ohto

Authors
  1. Masaharu Yoshikawa
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  2. Hiromitsu Saisho
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  3. Masaaki Ebara
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  4. Toshihiko Iijima
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  5. Shosuke Iwama
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  6. Fumio Endo
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  7. Michio Kimura
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  8. Yoshiyuki Shimamura
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  9. Yasutoshi Suzuki
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  10. Toshihiko Nakano
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  11. Yoshio Fukuyama
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  12. Kiyotaka Fujise
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  13. Masaji Nambu
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  14. Masao Ohto
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Yoshikawa, M., Saisho, H., Ebara, M. et al. A randomized trial of intrahepatic arterial infusion of 4′-epidoxorubicin with Lipiodol versus 4′-epidoxorubicin alone in the treatment of hepatocellular carcinoma. Cancer Chemother. Pharmacol. 33 (Suppl 1), S149–S152 (1994). https://doi.org/10.1007/BF00686689

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  • DOI: https://doi.org/10.1007/BF00686689

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