Abstract
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
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Reid, T., Yuen, A., Catolico, M. et al. Impact of omeprazole on the plasma clearance of methotrexate. Cancer Chemother. Pharmacol. 33, 82–84 (1993). https://doi.org/10.1007/BF00686028
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DOI: https://doi.org/10.1007/BF00686028