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Impact of omeprazole on the plasma clearance of methotrexate

  • Short Communication
  • Omeprazole, Methotrexate, Pharmacokinetics, Kidney
  • Published:
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Abstract

Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.

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Authors and Affiliations

  1. Division of Medical Oncology, Department of Medicine, Stanford University Medical Center, 94305, Stanford, CA, USA

    Tony Reid, Alan Yuen & Robert W. Carlson

  2. Department of Pharmacy, Stanford University Hospital, 94305, Stanford, CA, USA

    Marbel Catolico

Authors
  1. Tony Reid
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  2. Alan Yuen
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  3. Marbel Catolico
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  4. Robert W. Carlson
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Reid, T., Yuen, A., Catolico, M. et al. Impact of omeprazole on the plasma clearance of methotrexate. Cancer Chemother. Pharmacol. 33, 82–84 (1993). https://doi.org/10.1007/BF00686028

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  • DOI: https://doi.org/10.1007/BF00686028

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