Summary
To determine, if, as previously observed with rodent uterus, the 90 kilodalton heat shock protein (HSP-90) might be under estrogenic regulation in human mammary tumors, we analyzed its relationship with estrogen and progesterone receptors. A positive relationship between estrogen receptor and HSP-90 was observed when these were normalized to HSP-70 levels (to normalize for the intrinsic variations in each tumor, independent of any hormonal dependence).
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Shyamala, G., Schweitzer, M. & Ullrich, S.J. Relationship between 90-kilodalton heat shock protein, estrogen receptor, and progesterone receptor in human mammary tumors. Breast Cancer Res Tr 26, 95–100 (1993). https://doi.org/10.1007/BF00682704
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DOI: https://doi.org/10.1007/BF00682704