Summary
The current classification of renal-cell adenomas (RCAs) and carcinomas (RCCs) is based on eight basic cell and tumor types (entities) with characteristic morphologic features: (1) RCCs of clear-cell type, (2) RCAs/RCCs of chromophilic-cell type, (3) RCAs/RCCs of chromophobic-cell type, (4) RCCs of duct Bellini type, (5) RCCs of transitional-cell type, (6) RCCs of neuroendocrine type, (7) RCAs of oncocytic type, and (8) RCAs of metanephroid type. Tumors with a proposed histogenesis from the proximal tubule (clear-cell and chromophilic tumors) amount to 85% of renal cancers, whereas tumors with a proposed histogenesis from the connecting tubule/collecting duct (chromophobic-, oncocytic-, and duct Bellini-type tumors) amount to only 11%. The remaining tumor types represent rare entities (less than 1% each). Tumor cytogenetics data confirm the proposed eight morphologic subtypes and give further indications for type-specific tumor development and progression.
Similar content being viewed by others
References
Baer SC, Ro JY, Ordonez NG, Maiese RL, Loose JH, Grignon DG, Ayala AG (1993) Sarcomatoid collecting duct carcinoma: a clinicopathologic and immunohistochemical study of five cases. Hum Pathol 24:1017–1022
Berg E van den, Hout AH van der, Oosterhuis JW, Störkel S, Dijkhuizen T, Dam A, Zweers HMM, Mensink HJA, Buys CHCM, Jong B de (1993) Cytogenetic analysis of epithelial renal cell tumors: relationship with a new histopathological classification. Int J Cancer 55:223–227
Eble JN (1990) Tumors and tumor-like conditions of the kidneys and ureters. Contemporary issues in surgical pathology. Churchill Livingstone, New York Edinburgh London Melbourne
Füzesi L, Cober M, Mittermayer C (1992) Collecting duct carcinoma: cytogenetic characterization. Histopathology 21:155–160
Hartwick RW, Naggar AK el, Ro JY, Srigley JR, McLemore DD, Jones EC, Grignon DJ, Thomas MJ, Ayala AG (1992) Renal oncocytoma and granular cell carcinoma. A comparative clinicopathologic and DNA flow cytometric study. Am J Clin Pathol 98:587–593
Hout AH van der, Berg E van den, Vlies P van der, Dijkhuizen T, Störkel S, Oosterhuis JW, Jong B de, Buys CHCM (1993) Loss of heterozygosity at the short arm of chromosome 3 in renal cell cancer correlates with the cytological tumour type. Int J Cancer 53:353–357
Huettner PC, Bird DJ, Chang YC, Seiler WM (1991) Carcinoid tumor of the kidney with morphologic and immunohistochemical profile of a hindgut endocrine tumor: report of a case. Ultrastruct Pathol 15:655–661
Kovacs G (1989) Papillary renal cell carcinoma: a morphologic and cytogenetic study of 11 cases. Am J Pathol 134:27–34
Kovacs G, Szücs S, Eichner W, Maschek HJ, Wahnschaffe U, deRiese W (1987) Renal oncocytoma. A cytogenetic and morphologic study. Cancer 59:2071–2077
Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wie MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DR, Dean M, Glavac D, Richards RM, Crossey PA, Ferguson-Smith MA, Paslier DL, Chumakov I, Cohen D, Chinault C, Maher ER, Linehan WM, Zbar B, Lerman MI (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317–1320
Nagashima Y, Arai N, Tanaka Y, Yoshida S, Sumino K, Ohaki Y, Matsushita K, Morita T, Misugi K (1991) Two cases of renal epithelial tumour resembling immature nephron. Virchows Arch [A] 418:77–81
Pathak S, Strong LC, Ferrell RE; Trindade A (1982) Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217:939–941
Rumpelt HJ, Störkel S, Moll R, Schärfe T, Thoenes W (1991) Bellini duct carcinoma — further evidence for this rare variant of renal cell carcinoma. Histopathology 18:115–122
Speicher MR, Manoir S du, Schoell B, Schröck E, Ried T, Störkel S, Kovacs A, Cremer T, Kovacs G (1994) Specific loss of chromosomes 1, 2, 6, 10, 13, 17 and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol 145:356–364
Steinberg P, Störkel S, Oesch F, Thoenes W (1992) Carbohydrate metabolism in human renal clear cell carcinomas. Lab Invest 67:506–511
Störkel S (1993) Karzinome und Onkozytome der Niere. Gustav Fischer, Stuttgart Jena New York
Störkel S, Steart PV, Drenckhahn D, Thoenes W (1989) The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch [B] 56:237–245
Störkel S, Husmann G, Thoenes W (1992) Zur Diagnose und Differentialdiagnose des metanephroiden Nierentumors des Erwachsenen — ein unbekannter Nierentumor. Verh Dtsch Ges Pathol 76:306
Thoenes W, Störkel S, Rumpelt HJ (1985) Human chromophobe cell renal carcinoma. Virchows Arch [B] 48:207–217
Thoenes W, Störkel S, Rumpelt HJ (1986) Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histomorphological elements and their use for diagnostics. Pathol Res Pract 181:125–143
Thoenes W, Störkel S, Rumpelt HJ, Moll R (1990) Cytomorphological typing of renal cell carcinoma — a new approach. III. Warner Symposium: the operable renal cell carcinoma. Eur Urol 18:6–9
Zbar B, Brah H, Talmage C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327:721–724
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Störkel, S., van den Berg, E. Morphological classification of renal cancer. World J Urol 13, 153–158 (1995). https://doi.org/10.1007/BF00184870
Issue Date:
DOI: https://doi.org/10.1007/BF00184870