Abstract
Cancer cells are genetically predisposed to contribute to the formation of a malignant tumor. As a population they do not respect tissue boundaries, but penetrate into the surrounding normal tissues. On their way to lymph or blood vessels they create a path of destruction. This invasive behavior eventually gives access to the circulation, and opens a gate to metastatic dissemination(Nicolson et al.; Fidler and Hart 1982; Mareel et al. 1993).
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Bracke, M.E., Roy, F.M.V., Mareel, M.M. (1996). The E-cadherin/Catenin Complex in Invasion and Metastasis. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_9
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