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Tumor Models in Cancer Research

  • Book
  • © 2011

Overview

Editors:
  1. Beverly A. Teicher

    1. Genzyme Corporation, Boston, USA

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  • Comprehensively describes in a new, updated edition the state-of-the-art in animal tumor model research.
  • Includes syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models.
  • Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Perspectives on the History and Evolution of Tumor Models

      • Shannon Decker, Edward Sausville
      Pages 3-20

  3. Transplantable Syngeneic Rodent Tumors

    1. Front Matter

      Pages 21-21
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    2. Murine L1210 and P388 Leukemias

      • William R. Waud
      Pages 23-41

    3. Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice

      • Lisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White et al.
      Pages 43-78

    4. B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model

      • Enrique Alvarez
      Pages 79-95

  4. Human Tumor Xenografts

    1. Front Matter

      Pages 97-97
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    2. Human Tumor Xenograft Efficacy Models

      • Ming Liu, Daniel Hicklin
      Pages 99-124

    3. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real Time

      • Robert M. Hoffman
      Pages 125-166

    4. Patient-Derived Tumor Models and Explants

      • Heinz-Herbert Fiebig, Angelika M. Burger
      Pages 167-193

    5. The Pediatric Preclinical Testing Program

      • Christopher L. Morton, Peter J. Houghton
      Pages 195-213

    6. Imaging Efficacy in Tumor Models

      • Vinod Kaimal, Wilbur R. Leopold, Patrick McConville
      Pages 215-241

  5. Carcinogen-Induced Tumors

    1. Front Matter

      Pages 243-243
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    2. Mammary Cancer in Rats

      • Henry J. Thompson
      Pages 245-255

  6. Disease and Target-Specific Models

    1. Front Matter

      Pages 257-257
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    2. Animal Models of Melanoma

      • Ene T. Fairchild, William E. Carson III
      Pages 259-285

    3. Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approaches

      • Gilda G. Hillman
      Pages 287-305

    4. Animal Models of Mesothelioma

      • Harvey I. Pass, Joseph B. Pincus, Michele Carbone, Magdalena Plasilova
      Pages 307-324

    5. The Use of Mouse Models to Study Leukemia/Lymphoma and Assess Therapeutic Approaches

      • William Siders
      Pages 325-351
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Keywords

About this book

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Editors and Affiliations

  • Genzyme Corporation, Boston, USA

    Beverly A. Teicher

About the editor

Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

Bibliographic Information

  • Book Title: Tumor Models in Cancer Research

  • Editors: Beverly A. Teicher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-60761-968-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60761-967-3Published: 02 December 2010

  • Softcover ISBN: 978-1-62703-820-1Published: 28 November 2014

  • eBook ISBN: 978-1-60761-968-0Published: 01 December 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 2

  • Number of Pages: XIV, 693

  • Topics: Cancer Research, Pharmacology/Toxicology

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