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Classes and Prediction of Cell-Penetrating Peptides

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Cell-Penetrating Peptides

Part of the book series: Methods in Molecular Biology ((MIMB,volume 683))

Abstract

The classical view on how peptides enter cells has been changed due to the development in the research field of cell-penetrating peptides (CPPs). During the last 15 years, more than 100 peptide sequences have been published to enter cells and also to bring different biological cargoes with them. Here, we present an overview of CPPs, mainly trying to analyze their common properties yielding the prediction of their cell-penetrating properties. Furthermore, examples of recent research, ideas on classification and uptake mechanisms, as well as a summary of the therapeutic potential of CPPs are presented.

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Acknowledgements

The work presented in this article was supported by Swedish Research Council (VR-NT); by Center for Biomembrane Research, Stockholm; and by Knut and Alice Wallenberg’s Foundation.

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Authors and Affiliations

  1. Cepep II AB, Stockholm, Sweden

    Maria Lindgren

  2. Department of Neurochemistry, Stockholm University, Stockholm, Sweden

    Ülo Langel

  3. Laboratory of Molecular Biotechnology, Institute of Technology, Tartu University, Tartu, Estonia

    Ülo Langel

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  1. Maria Lindgren
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  2. Ülo Langel
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Correspondence to Maria Lindgren .

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Editors and Affiliations

  1. , Department of Neurochemistry, Stockholm University, Svante Arrheniusv 21A21A, Stockholm, 106 91, Sweden

    Ülo Langel

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Lindgren, M., Langel, Ü. (2011). Classes and Prediction of Cell-Penetrating Peptides. In: Langel, Ü. (eds) Cell-Penetrating Peptides. Methods in Molecular Biology, vol 683. Humana Press. https://doi.org/10.1007/978-1-60761-919-2_1

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  • DOI: https://doi.org/10.1007/978-1-60761-919-2_1

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-918-5

  • Online ISBN: 978-1-60761-919-2

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