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Post-Transcriptional Regulation by STAR Proteins pp 142–157Cite as

Reaching for the STARs

Linking RNA Binding Proteins to Diseases

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 693))

Abstract

The prototype STAR (Signal Transduction and Activation of RNA) protein is Sam68, the Src-associated substrate during mitosis of 68 kDa. Sam68, like all other STAR proteins, belongs to the large class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) domain family of RNA-binding proteins. The KH domain is an evolutionarily conserved RNA binding domain that consists of 70–100 amino acids. The KH domain is one of the most prevalent RNA binding domains that directly contacts single-stranded RNA with a signature topology. Sam68 contains a single KH domain that harbors additional conserved N- and C-terminal sequences also required for RNA binding specificity and dimerization. Sam68 frequently contains post-translational modifications including serine/threonine, tyrosine phosphorylation, lysine acetylation, arginine methylation and sumoylation. The phosphorylation of Sam68 or its association with SH3 domain containing proteins has been shown to influence its RNA binding activity. Hence Sam68 behaves as a STAR protein, whereby extracellular signals influence its ability to regulate RNA metabolism. Studies in mice have revealed physiological roles linking Sam68 to osteoporosis, cancer, infertility and ataxia. The role of Sam68, a closely related family member quaking (QKI), the KH domain and their links with human disease will be discussed in the present chapter.

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  1. Segal Cancer Centre, Lady Davis Institute, 3755 Côte Ste-Catherine Road, Montréal, Québec, Canada

    Stéphane Richard

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  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Talila Volk BSc, MSc, PhD

  2. Department of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, USA

    Karen Artzt BA, PhD

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© 2010 Landes Bioscience and Springer Science+Business Media

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Richard, S. (2010). Reaching for the STARs. In: Volk, T., Artzt, K. (eds) Post-Transcriptional Regulation by STAR Proteins. Advances in Experimental Medicine and Biology, vol 693. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7005-3_10

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