Regular ArticleMolecular Cloning and Chromosomal Localization of the Human Cyclin C (CCNC) and Cyclin E (CCNE) Genes: Deletion of theCCNCGene in Human Tumors
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Mammalian cell cycle cyclins
2020, Seminars in Cell and Developmental BiologyCitation Excerpt :Nuclear re-localization to the cytoplasm is thought to modulate Cdk8/Mediator activity thus regulating the transcription of stress-responsive genes [31]. Early after its discovery, cyclin C was found to display heterozygous mutations in acute lymphoblastic leukemia (ALL) and additional alterations in several tumor types including prostate cancers and osteosarcoma [32]. Following these observations, specific ablation of Ccnc in hematopoietic cells in a conditional knockout mouse model led to hyperplasia of thymocytes and T-cell ALL development in the presence of the LMO1 gene, a recurrent translocation product in human T-ALL [23].
Involvement of Mediator complex in malignancy
2014, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Single-strand conformational polymorphism analysis of the remaining CCNC allele from patients with a deletion of one allele established that there were no further mutations within the exons or the flanking intronic sequences. These results suggest that either CCNC haplo-insufficiency is enough to promote tumorigenesis or an important tumour suppressor gene is linked to the CCNC locus [135]. The first observation on the involvement of CCNC gene in HCC was obtained on a hepatoma cell line (HLE) that displayed up-regulation of this gene [130].
Target Genes of Vitamin D: Spatio-temporal interaction of chromatin, VDR, and response elements
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