REGULAR ARTICLEGene Structure, Sequence, and Chromosomal Localization of the Human Red Cell-Type Low-Molecular-Weight Acid Phosphotyrosyl Phosphatase Gene, ACP1
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Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?
2021, Advances in Cancer ResearchCitation Excerpt :The second lysine residue lies at the rim of the active site and helps in reducing the pKa of catalytic cysteine and stabilizing the incoming pTyr-substrate by providing a surface positive charge. While the E-loop is found in multiple conformations (β-hairpin ➔ fully disordered), the interaction of glutamate with PTP-loop arginine and role of lysines is conserved in all PTPs (Asante-Appiah et al., 2006; Eswaran et al., 2006; Iversen et al., 2002; Mitchell Bryson, Massa, Trask, & Van Etten, 1995). While the active site of PTP is conserved, there exists a broad range of PTP catalytic efficiencies.
Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme
2016, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :In 1973, Ferguson-Smith et al. assigned the genetic locus of acid phosphatase (ACP1) to the short arm of chromosome 2 [12]. Successively, based on extensive linkage data, other authors established the chromosomal localization of the ACP1 gene to the distal portion of 2p25 [13]. In 1993, Lazaruk et al. sequenced substantial portions of the ACP1*A, *B and *C alleles common to Europeans and identified six linearly positioned exons containing codons 14 to 157 as well as two exons of equal length (114 bp) interspaced by a short (41 bp) intron, encoding the specific fast and slow segments of the two variants originated by alternative RNA splicing [11].
Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates
2015, Bioorganic and Medicinal ChemistryCitation Excerpt :Both isoforms are single polypeptide chains of equal length which display difference only in a short sequence segment that corresponds to amino acid residues 40–73 in the mature protein. However, these isoforms present divergence in their physical chemistry properties, especially with respect to kinetics and consequently physiological functions.20–23 In recent years, PTPs have gained considerable attention as important drug targets.24
Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?
2009, American Journal of Obstetrics and GynecologyCitation Excerpt :The term ACP1 is normally used to indicate the gene, whereas the protein is usually indicated by the term low-molecular-weight protein-tyrosine–phosphatase (LMPTP). ACP1 is located on chromosome 2p25 and spans 7 exons and 6 introns.4 The enzyme is present in all tissue, and it is composed of 2 isoforms, called fast (F) and slow (S).
ACP1 and offspring sex ratio in smoking puerperae: A study at population level
2007, Early Human DevelopmentLow molecular weight protein tyrosine phosphatase (LMW-PTP) and its possible physiological functions of redox signaling in the eye lens
2007, Biochimica et Biophysica Acta - Proteins and Proteomics