Regular ArticleNeuroprotective Effects of Ginseng Total Saponin and Ginsenosides Rb1 and Rg1 on Spinal Cord Neurons in Vitro
References (70)
- et al.
Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury
Brain Res.
(1997) An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the rhesus monkey (Macaca mulatta)
J. Neurol. Sci.
(1978)- et al.
A neuroanatomical analysis of spinal cord injury in the rhesus monkey (Macaca mulatta)
J. Neurol. Sci.
(1976) - et al.
Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats
Brain Res.
(2000) - et al.
Glucocorticoid mechanisms in acute spinal cord injury: A review and therapeutic rationale
Surg. Neurol.
(1982) - et al.
Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice
J. Neurol. Sci.
(2000) - et al.
Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment
Exp. Neurol.
(2000) - et al.
The role of apoptosis and excitotoxicity in the death of spinal motoneurons and interneurons after neonatal nerve injury
Neuroscience
(1998) - et al.
Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root
Neurosci. Res.
(1997) - et al.
Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat
Exp. Neurol.
(1999)
Effects of NMDA receptor antagonists following spinal ischemia in the rabbit
Exp. Neurol.
(1990)
Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
Brain Res.
(2000)
Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice
Brain Res.
(1998)
Characteristics of BDNF-induced weight loss
Exp. Neurol.
(1995)
Glutamate neurotoxicity in spinal cord cell culture
Neuroscience
(1991)
Potentiation of the NGF-mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia
Jpn. J. Pharmacol.
(1977)
Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain
Brain Res. Mol. Brain Res.
(1997)
Excitotoxicity of glutamate and four analogs in primary spinal cord cell cultures
Neurochem. Int.
(1994)
Spinal cord neurons are vulnerable to rapidly triggered kainate neurotoxicity in vitro
Brain Res.
(1995)
Lipid peroxidation in experimental spinal cord injury: Time-level relationship
Neurosurg. Rev.
(1993)
Effects of ginsenoside Rb1 on central cholinergic metabolism
Pharmacology
(1991)
Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures
Proc. Natl. Acad. Sci. USA
(1995)
NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
Eur. J. Neurosci.
(1999)
A new 21-aminosteroid antioxidant lacking glucocorticoid activity stimulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells
J. Pharmacol. Exp. Ther.
(1988)
New substances of plant origin which increase nonspecific resistance
Annu. Rev. Pharmacol.
(1969)
Excitotoxic cell death
J. Neurobiol.
(1992)
Anti-lipid peroxidation and protection of ginsenosides against cerebral ischemia–reperfusion injuries in rats
Zhongguo Yao Li Xue Bao
(1990)
Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys [Published erratum appears in Nat. Med. 1997 Feb;3(2):240]
Nat. Med.
(1997)
Spinal cord injury. Review of basic and applied research
Spine
(1981)
Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat
Ann. Neurol.
(1994)
Experimental injury of the spinal cord
Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
Eur. J. Neurosci.
(1994)
N-Methyl-d-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: Behavioral, anatomic, and neurochemical studies
J. Neurotrauma
(1988)
A potential role for excitotoxins in the pathophysiology of spinal cord injury
Ann. Neurol.
(1988)
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Newly identified maltol derivatives in Korean Red Ginseng and their biological influence as antioxidant and anti-inflammatory agents
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2023, Pharmacognosy: Fundamentals, Applications, and Strategies, Second EditionSalvadora persica protects libido by reducing corticosterone and elevating the testosterone levels in chronic cigarette smoke exposure rats
2021, Saudi Journal of Biological SciencesCitation Excerpt :These findings can be confirmed from the present study data, where ginseng (100 mg/kg) improved the orientation and sexual activity characteristics in cigarette smoke-exposed rats (Table 1 and 2). There is strong evidence that indicates that the presence of ginsenosides in ginseng could be responsible for this activity and can be linked to its antioxidant potential (Liao et al., 2002). Another finding of this study is that cigarette smoke exposure adversely affected the serum levels of corticosterone and testosterone (Figs. 1 and 2).
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