Regular ArticleA Role for the de Novo Sphingolipids in Apoptosis of Photosensitized Cells
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2016, Journal of Photochemistry and Photobiology B: BiologyRegulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1
2015, Advances in Biological RegulationCitation Excerpt :Considerable evidence indicates that the regulation of de novo sphingolipid biosynthesis has important consequences for cellular physiology. For example biosynthesis of ceramide as a pro-apoptotic signal has been observed when cells are stressed with heat stress (Jenkins et al., 2002), sepsis and inflammatory cytokines (Memon et al., 1998), UV irradiation (Mullen et al., 2011; Panjarian et al., 2008; Uchida et al., 2003; Wispriyono et al., 2002), oxidative damage (Son et al., 2007) and the treatment of cells with a variety of chemotherapeutic compounds including daunorubicin (Bose et al., 1995), kinase and histone deacetylase inhibitors (Park et al., 2010), camptothecin and doxorubicin (Rath et al., 2009), cyclooxygenase inhibitors (Schiffmann et al., 2009), arsenic trioxide (Dbaibo et al., 2007), androgen ablation (Eto et al., 2003), fenretinide (Wang et al., 2001), and taxol (Charles et al., 2001; reviewed in Perry, 2000). Here we explore the mechanisms that control the biosynthesis of sphingolipids, particularly ceramide, to characterize the role of the ORMDLs and sphingosine kinase in the regulation of sphingolipid biosynthesis in both unstressed and stressed cells.
Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors
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2011, Biochemical and Biophysical Research CommunicationsMolecular effectors of multiple cell death pathways initiated by photodynamic therapy
2007, Biochimica et Biophysica Acta - Reviews on Cancer
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These authors contributed equally to this article.
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