Regular ArticleTransient Overexpression of Murine Dishevelled Genes Results in Apoptotic Cell Death
References (81)
- et al.
Wnt genes
Cell
(1992) - et al.
Wnts modulate cell fate and behavior during vertebrate development
Trends Genet.
(1997) - et al.
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
Cell
(1982) Serpentine proteins slither into the Wingless and Hedgehog fields
Cell
(1996)- et al.
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
Cell
(1997) - et al.
The midbrain–hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
Cell
(1992) - et al.
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled
Dev. Biol.
(1994) - et al.
Conservation of dishevelled structure and function between flies and mice: Isolation and characterization of Dvl2
Mech. Dev.
(1996) - et al.
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Cell
(1997) - et al.
The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
Cell
(1997)
DHR domains in syntrophins, neuronal NO synthetase and other intracellular proteins
Trends Biochem.
Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
Cell
Pleckstrin's repeat performance: A novel domain in G-protein signaling
Trends Biochem. Sci.
A frizzled homolog functions in a vertebrate Wnt signaling pathway
Curr. Biol.
Dishevelled proteins lead to two signaling pathways: Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
J. Biol. Chem.
Characterization of mouse Dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
J. Biol. Chem.
Human dishevelled genes constitute a DHR-containing multigene family
Genomics
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
Cell
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line
Cell
Analysis of dishevelled signaling pathways during Xenopus development
Curr. Biol.
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
Cell
Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
Cell
Regulation and function of the JNK subgroup of MAP kinases
Biochim. Biophys. Acta
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
J. Biol. Chem.
Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland
Differentiation
Localization and quantification of Wnt-2 gene expression in mouse mammary development
Dev. Biol.
Familial Alzheimer's disease associated with S182 codon 286 mutation
Lancet
Mutation analysis of presenilin 1 gene in Alzheimer's disease
Lancet
Direct association of presenilin-1 with β-catenin
FEBS Lett.
β-catenin: A key mediator of Wnt signaling
Curr. Opin. Genet. Dev.
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
Cell
Wnt signaling: A common theme in animal development
Genes Dev.
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal
Genes Dev.
dishevelled and armadillo act in the wingless signaling pathway in Drosophila
Nature
wingless signal and zeste-white 3 kinase trigger opposing changes in the intracellular distribution of armadillo
Development
Components of wingless signaling in Drosophila
Nature
Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
Nature
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion
J. Cell. Biol.
dishevelled is required during wingless signaling to establish both cell polarity and cell identity
Development
Isolation and characterization of mouse Dishevelled-3
Dev. Dyn.
Cited by (17)
Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats
2020, Neuroscience LettersCitation Excerpt :DVL-1 has been reported highly expressed at embryonic and postnatal stages of development in the central nervous system [11]. Overexpression of DVL-1 could cause cell death because of induction of apoptosis through JNK activating [12]. On the other side, DVL-1 could directly interact with p65 and repress the DNA-binding activity of NF-Κb [13].
R-spondin-1 is a novel β-cell growth factor and insulin secretagogue
2010, Journal of Biological ChemistryCitation Excerpt :Consistent with previous results in INS-1E β-cells (14), we found that cytokine treatment increased cleaved caspase3 activity in the MIN6 β-cells, whereas treatment with EX4 decreased cytokine-induced caspase3 levels. However, in addition to proliferation, several downstream mediators of cWnt signaling has been found to regulate apoptosis in a variety of cell types, including β-cells (35–42). The present study shows, for the first time, that Rspo1 inhibits cytokine-induced apoptosis in the MIN6 β-cells.
Protease-activated receptor-1 (PAR1) acts via a novel Gα <inf>13</inf>-dishevelled axis to stabilize β-catenin levels
2010, Journal of Biological ChemistryCitation Excerpt :Similarly, elicited levels of DVL3 have been demonstrated in malignant mesotheliomas and lung cancer (32, 33). DVL is composed of several structural domains: a DIX binding domain located at the N terminus, a PDZ domain in the midregion, and a DEP domain located about midway between the PDZ domain and the C terminus of DVL (34, 35). Although the DIX domain enables the dimerization of DVL with other members of the family as well as with axin (36), the PDZ domain provides a docking site for the C terminus of Fz receptors (37).
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3
2008, Cellular SignallingOverexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by β-catenin
2001, Experimental Cell Research
- 1
To whom correspondence and reprint requests should be addressed. Fax: (410) 706-6105. E-mail: [email protected].