Biochemical and Biophysical Research Communications
Regular Article2-Methoxyestradiol Induces G2/M Arrest and Apoptosis in Prostate Cancer
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Cited by (99)
Upregulated cyclin B1/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: Role of Bcl-X<inf>L</inf> phosphorylation
2019, SteroidsCitation Excerpt :Earlier studies with other microtubule inhibitors have shown that microtubule disruption would lead to cell cycle arrest and ultimately apoptosis (reviewed in Refs. [17]). It is of note that most earlier studies, which were based on flow cytometric analysis of different cell populations, reported that treatment of human cancer cells with 2-methoxyestradiol increases the combined G2/M cell populations [18,19]. However, our earlier study based on morphological analysis revealed that 2-methoxyestradiol induces predominantly mitotic prometaphase arrest in human cancer cells, but not G2 phase arrest [20].
Novel multifunctional nanocarrier-mediated codelivery for targeting and treatment of prostate cancer
2019, Nanomaterials for Drug Delivery and TherapyAntiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines
2018, European Journal of Pharmaceutical SciencesDesign, synthesis and biological evaluation of novel 2-methoxyestradiol analogs as dual selective estrogen receptor modulators (SERMs) and antiangiogenic agents
2017, European Journal of Medicinal Chemistry
- 1
The first two authors contributed equally to this work.
- 2
Present address: Kuwait University, Faculty of Medicine, P.O. Box 24923, Safat, Kuwait 13110.
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To whom correspondence may be addressed at VAMC, GRECC (11-GRC), 1201 NW 16 Street, Miami, FL 33125. Fax: (305) 324-3365. E-mail: [email protected].