Biochemical and Biophysical Research Communications
Breakviews and ViewsRegulation of Pyruvate Kinase M Gene Expression☆
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Cited by (55)
Oxidative stress-induced alterations in retinal glucose metabolism in Retinitis Pigmentosa
2022, Free Radical Biology and MedicineCitation Excerpt :A major control point for the shift between reliance on the TCA cycle and glycolysis for energy production is pyruvate kinase, the rate limiting enzyme of glycolysis. There are 4 isozymes of pyruvate kinase, PKL, PKR, PKM1, and PKM2, which differ in their regulatory properties [19,20]. The predominant isozyme in photoreceptors is PKM2 [21,22] which is also predominant in cancer cells [23].
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation
2020, Journal of Biological ChemistryPyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
2015, Molecular CellCitation Excerpt :The M1 and M2 isoforms are produced by mutually exclusive alternative mRNA splicing of the PKM gene. Including exon 9 in the transcript generates PKM1, while including exon 10 generates PKM2 (Noguchi et al., 1986; Yamada and Noguchi, 1999). PKM2 is found in early embryonic cells, normal proliferating cells, and tumor cells, as well as in white fat, lung, retina, and pancreatic islets (Imamura and Tanaka, 1982; Mazurek, 2011).
Protein-tyrosine phosphatase 1B substrates and metabolic regulation
2015, Seminars in Cell and Developmental BiologyProtein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation
2013, Journal of Biological ChemistryThe regulation of cancer cell death and metabolism by extracellular matrix attachment
2012, Seminars in Cell and Developmental BiologyCitation Excerpt :PKM2 is expressed in a number of different cell types including all proliferating cells, especially tumor cells [35]. During development, PKM2 is gradually replaced by PKM1, however, during tumorigenesis tissue specific isoenzymes are lost and PKM2 expression is regained [35,36,38,39]. In 2008, it was discovered that the M2 splice isoform of PK is necessary for the shift to aerobic glycolysis seen in tumor cells, and that this shift in cellular metabolism promotes tumorigenicity [28].
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Staal, G. E. J.van Veelen, C. W. M.
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