PDOX

Open Access
High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy
TAKASHI HIGUCHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, SHINJI MIWA, KENTARO IGARASHI, HIROYUKI TSUCHIYA and ROBERT M. HOFFMAN

Anticancer Research October 2023, 43 (10) 4277-4284; DOI: https://doi.org/10.21873/anticanres.16622
Open Access
Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model
NORIYUKI MASAKI, QINGHONG HAN, CARISSA SAMONTE, NATHANIEL F. WU, CHIHIRO HOZUMI, JUSTIN WU, KOYA OBARA, YUTARO KUBOTA, YUSUKE AOKI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research November 2022, 42 (11) 5217-5222; DOI: https://doi.org/10.21873/anticanres.16028
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Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2022, 42 (2) 731-737; DOI: https://doi.org/10.21873/anticanres.15531
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Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review
TAKASHI HIGUCHI, KENTARO IGARASHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, MICHAEL BOUVET, HIROYUKI TSUCHIYA and ROBERT M. HOFFMAN

Anticancer Research December 2021, 41 (12) 5865-5871; DOI: https://doi.org/10.21873/anticanres.15406
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A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response
TSUNEHISA NOMURA, JUNICHI KUREBAYASHI, TAKUYA MORIYA, WATARU SAITO, TAKUYA MURATA, JUN YAMAMOTO, CHIHIRO HOZUMI and ROBERT M. HOFFMAN

Anticancer Research December 2021, 41 (12) 6191-6197; DOI: https://doi.org/10.21873/anticanres.15438
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Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease
HIROMICHI OSHIRO, YASUNORI TOME, KENTARO MIYAKE, TAKASHI HIGUCHI, NORIHIKO SUGISAWA, FUMINORI KANAYA, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research July 2021, 41 (7) 3287-3292; DOI: https://doi.org/10.21873/anticanres.15115
Open Access
Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
YUSUKE AOKI, YASUNORI TOME, NATHANIEL F. WU, JUN YAMAMOTO, KAZUYUKI HAMADA, QINGHONG HAN, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research April 2021, 41 (4) 1745-1751; DOI: https://doi.org/10.21873/anticanres.14939
Open Access
Eribulin Inhibits Osteosarcoma in a Clinically-accurate Bone-tumor-insertion PDOX Mouse Model
NATHANIEL F. WU, JUN YAMAMOTO, YUSUKE AOKI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research April 2021, 41 (4) 1779-1784; DOI: https://doi.org/10.21873/anticanres.14943
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A Novel Orthotopic Mouse Model of Lung Metastasis Using Fluorescent Patient-derived Osteosarcoma Cells
HIROMICHI OSHIRO, YASUNORI TOME, KENTARO MIYAKE, TAKASHI HIGUCHI, NORIHIKO SUGISAWA, JUN HO PARK, ZHIYING ZHANG, SAHAR RAZMJOOEI, FUMINORI KANAYA, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2021, 41 (2) 635-640; DOI: https://doi.org/10.21873/anticanres.14814
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Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer
HAITAO YANG, ZHONG TONG, LEI SHEN, YU SUN, ROBERT M. HOFFMAN and JUN HUANG

Anticancer Research September 2020, 40 (9) 4969-4978; DOI: https://doi.org/10.21873/anticanres.14500

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