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Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2022, 42 (2) 731-737; DOI: https://doi.org/10.21873/anticanres.15531
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Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
YUSUKE AOKI, YASUNORI TOME, NATHANIEL F. WU, JUN YAMAMOTO, KAZUYUKI HAMADA, QINGHONG HAN, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research April 2021, 41 (4) 1745-1751; DOI: https://doi.org/10.21873/anticanres.14939
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Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis
YU SUN, HIROTO NISHINO, NORIHIKO SUGISAWA, JUN YAMAMOTO, KAZUYUKI HAMADA, GUANGWEI ZHU, HYE IN LIM and ROBERT M. HOFFMAN

Anticancer Research November 2020, 40 (11) 6083-6091; DOI: https://doi.org/10.21873/anticanres.14629
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A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy
NORIHIKO SUGISAWA, HIROTO NISHINO, TAKASHI HIGUCHI, JUN HO PARK, JUN YAMAMOTO, YOSHIHIKO TASHIRO, KEI KAWAGUCHI, MICHAEL BOUVET, MICHIAKI UNNO and ROBERT M. HOFFMAN

Anticancer Research October 2020, 40 (10) 5393-5397; DOI: https://doi.org/10.21873/anticanres.14547
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A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib
JUN YAMAMOTO, TAKUYA MURATA, YOSHIHIKO TASHIRO, TAKASHI HIGUCHI, NORIHIKO SUGISAWA, HIROTO NISHINO, SACHIKO INUBUSHI, YU SUN, HYEIN LIM, KENTARO MIYAKE, ATSUSHI HONGO, TSUNEHISA NOMURA, WATARU SAITOH, TAKUYA MORIYA, HIROKAZU TANINO, CHIHIRO HOZUMI, MICHAEL BOUVET, SHREE RAM SINGH, ITARU ENDO and ROBERT M. HOFFMAN

Anticancer Research May 2020, 40 (5) 2509-2514; DOI: https://doi.org/10.21873/anticanres.14221
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Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma
KENTARO IGARASHI, KEI KAWAGUCHI, MING ZHAO, QINGHONG HAN, YUYING TAN, TASUKU KIYUNA, KENTARO MIYAKE, TAKASHI HIGUCHI, SCOTT D. NELSON, SARAH M. DRY, YUNFENG LI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, SHREE RAM SINGH, HIROYUKI TSUCHIYA and ROBERT M. HOFFMAN

Anticancer Research May 2020, 40 (5) 2515-2523; DOI: https://doi.org/10.21873/anticanres.14222
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Chronic Stimulation of the Autophagy-inducing Ingredient of Areca Nut Promotes Tumor Growth In Vivo Through Up-regulation of Tumoral Autophagy
CHANG-TA CHIU, SHYUN-YEU LIU, CHING-YU YEN, BANG-YEN LIU, ZI-YU SUN, CHUN-YI WU, JI-LUNG DENG, YOUNG-CHAU LIU and MEI-HUEI LIN

Anticancer Research January 2020, 40 (1) 221-227; DOI: https://doi.org/10.21873/anticanres.13943
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Color-coded Imaging of the Fate of Cancer-cell-derived Exosomes During Pancreatic Cancer Metastases in a Nude-mouse Model
TOMOYUKI SATAKE, ATSUSHI SUETSUGU, MIKI NAKAMURA, TAKAHIRO KUNISADA, SHIGETOYO SAJI, HISATAKA MORIWAKI, MASAHITO SHIMIZU and ROBERT M. HOFFMAN

Anticancer Research August 2019, 39 (8) 4055-4060; DOI: https://doi.org/10.21873/anticanres.13561
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Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer
HO KYOUNG HWANG, CHANG MOO KANG, SUNG HWAN LEE, TAKASHI MURAKAMI, TASUKU KIYUNA, SE HOON KIM, ROBERT M. HOFFMAN and MICHAEL BOUVET

Anticancer Research February 2018, 38 (2) 665-670;
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Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase
KENTARO IGARASHI, KEI KAWAGUCHI, TASUKU KIYUNA, KENTARO MIYAKE, TAKASHI MURAKAMI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, HIROYUKI TSUCHIYA and ROBERT M. HOFFMAN

Anticancer Research September 2017, 37 (9) 4807-4812;

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