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Glutamine Dependence Is Not a Cancer-specific Vulnerability in Contrast to Methionine Dependence
YUTA MIYASHI, KOHEI MIZUTA, YOHEI ASANO, BYUNG MO KANG, JIN SOO KIM, QINGHONG HAN, SHUKUAN LI, MICHAEL BOUVET, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2026, 46 (2) 749-755; DOI: https://doi.org/10.21873/anticanres.17984
Open Access
Effect of Recombinant Methioninase Dose and Timing on the Selective and Precise Elimination of Cancer Cells from Co-Cultured Normal Cells and on Methionine-dependent Rescue of Cancer Cells
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research January 2026, 46 (1) 143-151; DOI: https://doi.org/10.21873/anticanres.17930
Open Access
Recombinant Methioninase Selectively Eliminates Cancer Cells Co-cultured With Normal Fibroblasts Indicating the High-Precision Efficacy of Targeting Methionine Addiction of Cancer
BYUNG MO KANG, QINGHONG HAN, SHUKUAN LI, JIN SOO KIM, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research October 2025, 45 (10) 4193-4200; DOI: https://doi.org/10.21873/anticanres.17771
Open Access
Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells
DANIEL ARDJMAND, YUTARO KUBOTA, MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA and ROBERT M. HOFFMAN

Anticancer Research March 2024, 44 (3) 929-933; DOI: https://doi.org/10.21873/anticanres.16887

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normal cells