methotrexate

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Heterogeneous c-Met Activation in Osteosarcoma Dictates Synergistic Vulnerability to Combined c-Met Inhibition and Methotrexate Therapy
GUIDONG LI, HIROYUKI KAWASHIMA, TARO SASAKI, TAKASHI ARIIZUMI, NAOKI OIKE and AKIRA OGOSE

Anticancer Research July 2025, 45 (7) 2791-2806; DOI: https://doi.org/10.21873/anticanres.17648
Open Access
Super Methotrexate-resistant Osteosarcoma Cells Retain Their Sensitivity to Recombinant Methioninase: Targeting Methionine Addiction to Overcome Extreme Cancer-Chemotherapy Resistance
YUSUKE AOKI, QINGHONG HAN, YUTARO KUBOTA, NORIYUKI MASAKI, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research March 2025, 45 (3) 929-934; DOI: https://doi.org/10.21873/anticanres.17480
Open Access
Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3
YUSUKE AOKI, YUTARO KUBOTA, NORIYUKI MASAKI, KOYA OBARA, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research October 2024, 44 (10) 4213-4218; DOI: https://doi.org/10.21873/anticanres.17251
Open Access
Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression
YUSUKE AOKI, YUTARO KUBOTA, NORIYUKI MASAKI, KOYA OBARA, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research July 2024, 44 (7) 2787-2792; DOI: https://doi.org/10.21873/anticanres.17090
Open Access
Pharmacokinetics and Pharmacodynamics of Glucarpidase Rescue Treatment After High-dose Methotrexate Therapy Based on Modeling and Simulation
TOSHIMI KIMURA, YUTAKA FUKAYA, YUKIHIRO HAMADA, KENICHI YOSHIMURA and HIROSHI KAWAMOTO

Anticancer Research May 2023, 43 (5) 1919-1924; DOI: https://doi.org/10.21873/anticanres.16351
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Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model
YUSUKE AOKI, YASUNORI TOME, QINGHONG HAN, JUN YAMAMOTO, KAZUYUKI HAMADA, NORIYUKI MASAKI, YUTARO KUBOTA, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2022, 42 (2) 731-737; DOI: https://doi.org/10.21873/anticanres.15531
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Effect of Monoammonium Glycyrrhizinate on the Development of Hepatotoxicity After Initial Intrathecal Chemotherapy for Leukemia
KENJI KISHIMOTO, DAIICHIRO HASEGAWA, SUGURU UEMURA, SAYAKA NAKAMURA, AIKO KOZAKI, ATSURO SAITO, TOSHIAKI ISHIDA, TAKESHI MORI and YOSHIYUKI KOSAKA

Anticancer Research December 2021, 41 (12) 6231-6236; DOI: https://doi.org/10.21873/anticanres.15443
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From ‘Targeted Therapy’ to Targeted Therapy
GODEFRIDUS J. PETERS

Anticancer Research July 2019, 39 (7) 3341-3345; DOI: https://doi.org/10.21873/anticanres.13476
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Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells
PATRYCJA WIŃSKA, ŁUKASZ WIDŁO, KATARZYNA SKIERKA, ALICJA KRZYŚKO, MIROSŁAWA KORONKIEWICZ, JAROSŁAW M. CIEŚLA, JOANNA CIEŚLA and MARIA BRETNER

Anticancer Research July 2019, 39 (7) 3531-3542; DOI: https://doi.org/10.21873/anticanres.13499
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Prognosis of Patients with Gestational Trophoblastic Neoplasia and Obstetric Outcomes of Those Conceiving After Chemotherapy
ANGIOLO GADDUCCI, STEFANIA COSIO, ANTONIO FANUCCHI, ROBERTA TANA, SIMONA MANACORDA, SABINA PISTOLESI and FRANCESCA LETIZIA STRIGINI

Anticancer Research July 2016, 36 (7) 3477-3482;

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