methionine restriction

Open Access
Synergy of KRAS-inhibitor Daraxonrasib Combined With Recombinant Methioninase on Pancreatic-cancer Cells But Not Normal Cells
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, YUTA MIYASHI, TOMOYUKI ISHIGURO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research September 2026, 46 (9) 4859-4865; DOI: https://doi.org/10.21873/anticanres.18338
Open Access
Sulfasalazine an Inhibitor of System x_C⁻ (Cystine/glutamate Antiporter), Combined With Recombinant Methioninase, Inhibits Both Cancer and Normal Cells, Suggesting Lack of Cancer Selectivity of Cysteine Restriction
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, YUTA MIYASHI, TOMOYUKI ISHIGURO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research May 2026, 46 (5) 2353-2359; DOI: https://doi.org/10.21873/anticanres.18122
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Glutamine Dependence Is Not a Cancer-specific Vulnerability in Contrast to Methionine Dependence
YUTA MIYASHI, KOHEI MIZUTA, YOHEI ASANO, BYUNG MO KANG, JIN SOO KIM, QINGHONG HAN, SHUKUAN LI, MICHAEL BOUVET, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research February 2026, 46 (2) 749-755; DOI: https://doi.org/10.21873/anticanres.17984
Open Access
The Conditions of Non-rescuability of Methioninase-treated Cancer Cells by Methionine Replenishment: The Point of No Return
BYUNG MO KANG, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, JIN SOO KIM, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research July 2025, 45 (7) 2817-2823; DOI: https://doi.org/10.21873/anticanres.17650
Open Access
Efficacy of Methionine Restriction and the PARP-inhibitor Olaparib and Their Combination on BRCA1 Mutant and Wild-type Triple-negative Breast Cancer Cell Lines
MAYUKO MIKI, SACHIKO INUBUSHI, QINGHONG HAN, SHOTARO INOUE, TOMONARI KUNIHISA, HIROKAZU TANINO and ROBERT M. HOFFMAN

Anticancer Research April 2025, 45 (4) 1367-1372; DOI: https://doi.org/10.21873/anticanres.17522
Open Access
Super Methotrexate-resistant Osteosarcoma Cells Retain Their Sensitivity to Recombinant Methioninase: Targeting Methionine Addiction to Overcome Extreme Cancer-Chemotherapy Resistance
YUSUKE AOKI, QINGHONG HAN, YUTARO KUBOTA, NORIYUKI MASAKI, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research March 2025, 45 (3) 929-934; DOI: https://doi.org/10.21873/anticanres.17480
Open Access
Comparison of Cell-death Kinetics of Recombinant Methioninase (rMETase)-treated Cancer and Normal Cells: Only Cancer Cells Undergo Methionine-depletion Catastrophe at Low rMETase Concentrations
BYUNG MO KANG, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research January 2025, 45 (1) 105-111; DOI: https://doi.org/10.21873/anticanres.17397
Open Access
Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3777-3783; DOI: https://doi.org/10.21873/anticanres.17202
Open Access
Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG M KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3785-3791; DOI: https://doi.org/10.21873/anticanres.17203
Open Access
First-line Chemotherapy in Combination With Oral Recombinant Methioninase and a Low-methionine Diet for a Stage IV Inoperable Pancreatic-Cancer Patient Resulted in 40% Tumor Reduction and an 86% CA19-9 Biomarker Decrease
MOTOKAZU SATO, QINGHONG HAN, CHIHIRO HOZUMI, HIDEO KUJIRAOKA, KOHEI MIZUTA, SEI MORINAGA, BYUNG MO KANG, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3885-3889; DOI: https://doi.org/10.21873/anticanres.17215

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