Methioninase

Open Access
Recombinant Methioninase Selectively Eliminates Cancer Cells Co-cultured With Normal Fibroblasts Indicating the High-Precision Efficacy of Targeting Methionine Addiction of Cancer
BYUNG MO KANG, QINGHONG HAN, SHUKUAN LI, JIN SOO KIM, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research October 2025, 45 (10) 4193-4200; DOI: https://doi.org/10.21873/anticanres.17771
Open Access
The Triple Combination of Recombinant Methioninase, Rapamycin, and Chloroquine Synergistically Eradicates HCT116 Colon Cancer Cells
JINSOO KIM, QINGHONG HAN, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research July 2025, 45 (7) 2773-2779; DOI: https://doi.org/10.21873/anticanres.17646
Open Access
The Conditions of Non-rescuability of Methioninase-treated Cancer Cells by Methionine Replenishment: The Point of No Return
BYUNG MO KANG, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, JIN SOO KIM, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research July 2025, 45 (7) 2817-2823; DOI: https://doi.org/10.21873/anticanres.17650
Open Access
Combination of Recombinant Methioninase With Rapamycin or Chloroquine Is Synergistic to Highly Inhibit Triple-negative Breast Cancer Cells In Vitro
JINSOO KIM, QINGHONG HAN, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research May 2025, 45 (5) 1853-1859; DOI: https://doi.org/10.21873/anticanres.17564
Open Access
Comparison of Cell-death Kinetics of Recombinant Methioninase (rMETase)-treated Cancer and Normal Cells: Only Cancer Cells Undergo Methionine-depletion Catastrophe at Low rMETase Concentrations
BYUNG MO KANG, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research January 2025, 45 (1) 105-111; DOI: https://doi.org/10.21873/anticanres.17397
Open Access
Recombinant Methioninase Synergistically Reverses High-docetaxel Resistance Developed in Osteosarcoma Cells
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG M. KANG, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research November 2024, 44 (11) 4773-4778; DOI: https://doi.org/10.21873/anticanres.17303
Open Access
Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3777-3783; DOI: https://doi.org/10.21873/anticanres.17202
Open Access
Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG M KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3785-3791; DOI: https://doi.org/10.21873/anticanres.17203
Open Access
Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research August 2024, 44 (8) 3261-3268; DOI: https://doi.org/10.21873/anticanres.17144
Open Access
DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts
SEI MORINAGA, QINGHONG HAN, YUTARO KUBOTA, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research June 2024, 44 (6) 2359-2367; DOI: https://doi.org/10.21873/anticanres.17043

Main menu

User menu

Search

Methioninase

Pages