combination therapy

Open Access
Simultaneous Targeting of Multiple Hallmarks of Cancer With Recombinant Methioninase, Rapamycin and Chloroquine Is Specific and Synergistic to MiaPaCa-2 Pancreatic-Cancer Cells in Contrast to Hs-27 Normal Fibroblasts
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research November 2025, 45 (11) 4765-4770; DOI: https://doi.org/10.21873/anticanres.17825
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JI-CJ002, a Natural Herbal Formula, Enhances the Antitumor Efficacy of FOLFOX in Colorectal Cancer by Suppressing the DDR Pathway
MIN-WOO KIM, DAEUN KIM, SANG-EUN LEE, JAEHAK AHN, BYUNGHAK PARK, CHUNHOO CHEON and SEONG-GYU KO

Anticancer Research November 2025, 45 (11) 4987-5000; DOI: https://doi.org/10.21873/anticanres.17841
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Efficacy and Safety of Chemoimmunotherapy in Patients With Advanced Non-small Cell Lung Cancer With Pre-existing Interstitial Pneumonia and Low PD-L1 Expression
AOSA SASADA, HAYATO KAWACHI, TADAAKI YAMADA, TAE HATA, YASUHIRO GOTO, AKIHIKO AMANO, YOSHIKI NEGI, SATOSHI WATANABE, NAOKI FURUYA, TOMOHIRO OBA, TATSUKI IKOMA, AKIRA NAKAO, KEIKO TANIMURA, HIROKAZU TANIGUCHI, AKIHIRO YOSHIMURA, TOMOYA FUKUI, DAIKI MURATA, KYOICHI KAIRA, SHINSUKE SHIOTSU, ASUKA OKADA, YUSUKE CHIHARA, TAKASHI KIJIMA and KOICHI TAKAYAMA

Anticancer Research November 2025, 45 (11) 5045-5057; DOI: https://doi.org/10.21873/anticanres.17845
Open Access
Very Rapid Eradication of a Large Squamous-Cell Carcinoma of the Head and Neck Treated With First-line Combination Chemotherapy, a Low-methionine Diet, and Oral Recombinant Methioninase
YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, BYUNG MO KANG, JIN SOO KIM, YUTA MIYASHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research November 2025, 45 (11) 5225-5231; DOI: https://doi.org/10.21873/anticanres.17862
Open Access
Combinations of Salmonella typhimurium A1-R, Recombinant Methioninase, and Chloroquine, Each Targeting Fundamental Cancer Hallmarks, Are Selectively Effective on Colon Cancer Cells Compared to Normal Fibroblasts
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MING ZHAO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research September 2025, 45 (9) 3661-3668; DOI: https://doi.org/10.21873/anticanres.17729
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A Novel Three Small Molecule Inhibitor Combination Therapy For Prostate Cancer
UMMUHAN DEMIR, HILAL BADOGLU, IREM NUR CETIN and MUHAMMED YASAR BENER

Anticancer Research July 2025, 45 (7) 3077-3087; DOI: https://doi.org/10.21873/anticanres.17672
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Comparing Immuno-oncology Combination Therapy With Tyrosine Kinase Inhibitor Monotherapy for Advanced Renal Cell Carcinoma
GAKU ISHIKAWA, KEITA TAMURA, YOSHIHIRO TSUCHIYA, SHUNSUKE WATANABE, TAKEMURA AYANA, SANO ASUKA, KYOHEI WATANABE, HIROMITSU WATANABE, YUTO MATSUSHITA, DAISUKE MOTOYAMA, ATSUSHI OTSUKA and TERUO INAMOTO

Anticancer Research January 2025, 45 (1) 379-386; DOI: https://doi.org/10.21873/anticanres.17426
Open Access
First-line Chemotherapy in Combination With Oral Recombinant Methioninase and a Low-methionine Diet for a Stage IV Inoperable Pancreatic-Cancer Patient Resulted in 40% Tumor Reduction and an 86% CA19-9 Biomarker Decrease
MOTOKAZU SATO, QINGHONG HAN, CHIHIRO HOZUMI, HIDEO KUJIRAOKA, KOHEI MIZUTA, SEI MORINAGA, BYUNG MO KANG, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

Anticancer Research September 2024, 44 (9) 3885-3889; DOI: https://doi.org/10.21873/anticanres.17215
Open Access
Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet
MOTOKAZU SATO, QINGHONG HAN, RYOSUKE MORI, KOHEI MIZUTA, BYUNG MO KANG, SEI MORINAGA, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

Anticancer Research April 2024, 44 (4) 1499-1504; DOI: https://doi.org/10.21873/anticanres.16946
Open Access
Recombinant Methioninase Decreased the Effective Dose of Irinotecan by 15-fold Against Colon Cancer Cells: A Strategy for Effective Low-toxicity Treatment of Colon Cancer
MOTOKAZU SATO, QINGHONG HAN, YUTARO KUBOTA, ANTON BARANOV, DANIEL ARDJMAND, KOHEI MIZUTA, SEI MORINAGA, BYUNG MO KANG, NORITOSHI KOBAYASHI, MICHAEL BOUVET, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

Anticancer Research January 2024, 44 (1) 31-35; DOI: https://doi.org/10.21873/anticanres.16785

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