RT Journal Article
SR Electronic
T1 Disease-free Interval after Primary Treatment Predicts Prognosis of Recurrent Endometrial Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4347
OP 4352
VO 30
IS 10
A1 YUTAKA UEDA
A1 YUKI MATSUMURA
A1 TOMOMI EGAWA-TAKATA
A1 TAKAHITO MIYAKE
A1 TAKASHI MIYATAKE
A1 KIYOSHI YOSHINO
A1 MASAMI FUJITA
A1 SHINYA MATSUZAKI
A1 TAKUHEI YOKOYAMA
A1 YUKARI MIYOSHI
A1 MASATO YAMASAKI
A1 TAKAYUKI ENOMOTO
A1 TADASHI KIMURA
YR 2010
UL http://ar.iiarjournals.org/content/30/10/4347.abstract
AB Aim: The aim of this study was to determine if the disease-free interval after initial surgical resection has any useful prognostic value for recurrent endometrial carcinoma patients. Patients and Methods: Between 1998 and 2007, complete resection of endometrial carcinoma was achieved in 536 cases at the Departments of Obstetrics and Gynecology of the Osaka University and Osaka Rosai Hospitals of Osaka, Japan. Clinical characteristics of these cases were retrospectively reviewed. Results: Recurrence was subsequently detected in 54 cases. Overall survival after recurrence in 27 patients with recurrences earlier than 12 months who received no postoperative therapy, radiation, and chemotherapy as an adjuvant therapy were significantly shorter than that of those with recurrences later than 12 months with similar treatments. Multivariate analysis demonstrated that the disease-free interval was an independent factor for prognosis. Conclusion: We demonstrate a significantly worse prognosis in cases with early versus late recurrence of resected endometrial carcinomas, irrespective of the type of adjuvant therapy.