RT Journal Article
SR Electronic
T1 L-type Amino-Acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-Chemoradiotherapy for Advanced Rectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4223
OP 4227
VO 30
IS 10
A1 TAKESHI EBARA
A1 KYOICHI KAIRA
A1 JUN-ICHI SAITO
A1 MARIKO SHIOYA
A1 TAKAYUKI ASAO
A1 TAKEO TAKAHASHI
A1 HIDEYUKI SAKURAI
A1 YOSHIKATSU KANAI
A1 HIROYUKI KUWANO
A1 TAKASHI NAKANO
YR 2010
UL http://ar.iiarjournals.org/content/30/10/4223.abstract
AB Aim: To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT). Patients and Methods: Forty-four patients with rectal adenocarcinoma who received neoadjuvant HCRT were investigated. LAT1 expression was immunohistochemically evaluated using pretreatment biopsies. The operation was performed after 2-3 months following HCRT and each resected specimen was graded by the histological criteria of the Japanese Classification of Colorectal Carcinoma. Results: A positive LAT1 expression was recognized in 50.0% (22/44) of patients. Resected specimens were divided into 2 groups according to the histological grading criteria: good response (n=29) and poor response (n=15). LAT1-negative tumours had an 81.8% probability of good response and 18.2% probability of poor response. LAT1 expression showed marginally significant association with response to HCRT (p=0.05). Conclusion: LAT1 may be a useful predictive marker of response to HCRT in rectal cancer.