RT Journal Article
SR Electronic
T1 Overexpression of Tissue Inhibitor of Metalloproteinase-1 Gene Correlates with Poor Outcomes in Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4127
OP 4130
VO 30
IS 10
A1 DAISUKE INAGAKI
A1 TAKASHI OSHIMA
A1 KAZUE YOSHIHARA
A1 SHUZO TAMURA
A1 AMANE KANAZAWA
A1 TAKANOBU YAMADA
A1 NAOTO YAMAMOTO
A1 TSUTOMU SATO
A1 MANABU SHIOZAWA
A1 SOICHIRO MORINAGA
A1 MAKOTO AKAIKE
A1 SHOICHI FUJII
A1 KAZUSHI NUMATA
A1 CHIKARA KUNISAKI
A1 YASUSHI RINO
A1 KATSUAKI TANAKA
A1 MUNETAKA MASUDA
A1 TOSHIO IMADA
YR 2010
UL http://ar.iiarjournals.org/content/30/10/4127.abstract
AB Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a major endogenous regulator of matrix metalloproteinases. This study examined the relation between TIMP-1 gene expression and postoperative mortality in patients with colorectal cancer (CRC). Specimens of CRC were obtained from 202 patients. The relative expression levels of TIMP-1 mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction. The expression level of the TIMP-1 gene was categorized as low or high according to the median value. The TIMP-1 level did not correlate with any clinicopathological feature. On Kaplan-Meier analysis, the 5-year overall survival rate was significantly lower in patients with high TIMP-1 (62.6%) than in those with low TIMP-1 (80.6%; p=0.0113). High TIMP-1 mRNA expression was associated with significantly poorer overall survival on univariate Cox regression analysis (p=0.0013) and multivariate analysis (p=0.0070). Overexpression of TIMP-1 thus correlated with poor outcomes in patients with CRC. Our results suggest that the TIMP-1 gene expression level might be a useful, independent prognostic factor in CRC.