PT - JOURNAL ARTICLE AU - DAISUKE INAGAKI AU - TAKASHI OSHIMA AU - KAZUE YOSHIHARA AU - SHUZO TAMURA AU - AMANE KANAZAWA AU - TAKANOBU YAMADA AU - NAOTO YAMAMOTO AU - TSUTOMU SATO AU - MANABU SHIOZAWA AU - SOICHIRO MORINAGA AU - MAKOTO AKAIKE AU - SHOICHI FUJII AU - KAZUSHI NUMATA AU - CHIKARA KUNISAKI AU - YASUSHI RINO AU - KATSUAKI TANAKA AU - MUNETAKA MASUDA AU - TOSHIO IMADA TI - Overexpression of Tissue Inhibitor of Metalloproteinase-1 Gene Correlates with Poor Outcomes in Colorectal Cancer DP - 2010 Oct 01 TA - Anticancer Research PG - 4127--4130 VI - 30 IP - 10 4099 - http://ar.iiarjournals.org/content/30/10/4127.short 4100 - http://ar.iiarjournals.org/content/30/10/4127.full SO - Anticancer Res2010 Oct 01; 30 AB - Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a major endogenous regulator of matrix metalloproteinases. This study examined the relation between TIMP-1 gene expression and postoperative mortality in patients with colorectal cancer (CRC). Specimens of CRC were obtained from 202 patients. The relative expression levels of TIMP-1 mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction. The expression level of the TIMP-1 gene was categorized as low or high according to the median value. The TIMP-1 level did not correlate with any clinicopathological feature. On Kaplan-Meier analysis, the 5-year overall survival rate was significantly lower in patients with high TIMP-1 (62.6%) than in those with low TIMP-1 (80.6%; p=0.0113). High TIMP-1 mRNA expression was associated with significantly poorer overall survival on univariate Cox regression analysis (p=0.0013) and multivariate analysis (p=0.0070). Overexpression of TIMP-1 thus correlated with poor outcomes in patients with CRC. Our results suggest that the TIMP-1 gene expression level might be a useful, independent prognostic factor in CRC.