TY - JOUR T1 - A Phase II Trial of Calcitriol and Naproxen in Recurrent Prostate Cancer JF - Anticancer Research JO - Anticancer Res SP - 3605 LP - 3610 VL - 29 IS - 9 AU - SANDY SRINIVAS AU - DAVID FELDMAN Y1 - 2009/09/01 UR - http://ar.iiarjournals.org/content/29/9/3605.abstract N2 - Background: Androgen-deprivation therapy is commonly used in patients with progressive prostate cancer (PCa), but can be associated with unpleasant side-effects. The objective of the study was to determine whether treatment with calcitriol and naproxen is effective in safely delaying the growth and progression of PCa in men with early recurrent disease. Materials and Methods: Patients with biochemical relapse after local therapy for prostate cancer were treated with high dose calcitriol (DN101, Novacea) (45 μg once per week) and naproxen (375 mg twice daily) for one year and followed with serum PSA levels as well as imaging studies. Results: Twenty-one patients were enrolled in the trial. Four patients met criteria for progression, with a PSA doubling time (PSADT) that decreased while on therapy. Fourteen patients had a prolongation of PSADT compared to baseline. Conclusion: Combination therapy with weekly calcitriol and daily naproxen is well tolerated by most patients and prolongation of PSADT was achieved in 75% of patients. ER -