RT Journal Article
SR Electronic
T1 The Impact of 1,25(OH)2D3 and its Structural Analogs on Gene Expression in Cancer Cells - A Microarray Approach
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3471
OP 3483
VO 29
IS 9
A1 CARSTEN KRIEBITZSCH
A1 LIEVE VERLINDEN
A1 GUY EELEN
A1 BIAUW KENG TAN
A1 MARK VAN CAMP
A1 ROGER BOUILLON
A1 ANNEMIEKE VERSTUYF
YR 2009
UL http://ar.iiarjournals.org/content/29/9/3471.abstract
AB The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], is an important regulator of bone metabolism, calcium and phosphate homeostasis but also has potent antiproliferative and pro-differentiating effects on a wide variety of cell types. To identify key genes that are (directly) regulated by 1,25(OH)2D3, a large number of microarray studies have been performed on different types of cancer cells (prostate, breast, ovarian, colorectal, squamous cell carcinoma and leukemia). The variety of target genes identified through these studies reflects the pleiotropic action of 1,25(OH)2D3. Common cellular processes targeted by 1,25(OH)2D3 in the different cancer cell lines include cell cycle progression, apoptosis, cellular adhesion, oxidative stress, immune function and steroid metabolism. Upon comparison of the lists of genes regulated by 1,25(OH)2D3 in the different microarray studies, only a small set of individual genes were commonly regulated, among which are included 24-hydroxylase, growth arrest and DNA-damage-inducible protein, cathelicidin antimicrobial peptide and multiple cyclins.