RT Journal Article SR Electronic T1 Effect of Aromatase Inhibitors on Lipid Metabolism, Inflammatory Response and Antioxidant Balance in Patients with Breast Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3337 OP 3346 VO 29 IS 8 A1 BOHUSLAV MELICHAR A1 HANA KALÁBOVÁ A1 LENKA KRČMOVÁ A1 LUBOR URBÁNEK A1 RADOMÍR HYŠPLER A1 DAGMAR SOLICHOVÁ A1 KAROLINA MELICHAROVÁ A1 MIROSLAV PECKA A1 ZDENĚK ZADÁK YR 2009 UL http://ar.iiarjournals.org/content/29/8/3337.abstract AB Background: Aromatase inhibitors may affect lipid metabolism, inflammatory response and antioxidant balance. Patients and Methods: One hundred and eighty-six post-menopausal patients with breast carcinoma underwent evaluation of parameters of lipid metabolism, inflammatory response and antioxidant balance immediately before as well as 2 and 4 months after the start of therapy with aromatase inhibitors. Results: A significant increase in total, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol, lipoprotein (a), retinol, C-reactive protein and fibrinogen was observed. The changes of serum lipid concentrations were restricted mostly to the patients pre-treated with tamoxifen who had significantly lower baseline levels of these parameters. Conclusion: An increase of serum cholesterol, lipoprotein (a), C-reactive protein and fibrinogen in patients treated with aromatase inhibitors is the result of tamoxifen withdrawal rather than a direct effect of therapy. No significant changes in serum lipids were observed in patients treated with aromatase inhibitors in the first-line setting.