PT  - JOURNAL ARTICLE
AU  - BOHUSLAV MELICHAR
AU  - HANA KALÁBOVÁ
AU  - LENKA KRČMOVÁ
AU  - LUBOR URBÁNEK
AU  - RADOMÍR HYŠPLER
AU  - DAGMAR SOLICHOVÁ
AU  - KAROLINA MELICHAROVÁ
AU  - MIROSLAV PECKA
AU  - ZDENĚK ZADÁK
TI  - Effect of Aromatase Inhibitors on Lipid Metabolism, Inflammatory Response and Antioxidant Balance in Patients with Breast Carcinoma
DP  - 2009 Aug 01
TA  - Anticancer Research
PG  - 3337--3346
VI  - 29
IP  - 8
4099  - http://ar.iiarjournals.org/content/29/8/3337.short
4100  - http://ar.iiarjournals.org/content/29/8/3337.full
SO  - Anticancer Res2009 Aug 01; 29
AB  - Background: Aromatase inhibitors may affect lipid metabolism, inflammatory response and antioxidant balance. Patients and Methods: One hundred and eighty-six post-menopausal patients with breast carcinoma underwent evaluation of parameters of lipid metabolism, inflammatory response and antioxidant balance immediately before as well as 2 and 4 months after the start of therapy with aromatase inhibitors. Results: A significant increase in total, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol, lipoprotein (a), retinol, C-reactive protein and fibrinogen was observed. The changes of serum lipid concentrations were restricted mostly to the patients pre-treated with tamoxifen who had significantly lower baseline levels of these parameters. Conclusion: An increase of serum cholesterol, lipoprotein (a), C-reactive protein and fibrinogen in patients treated with aromatase inhibitors is the result of tamoxifen withdrawal rather than a direct effect of therapy. No significant changes in serum lipids were observed in patients treated with aromatase inhibitors in the first-line setting.