PT  - JOURNAL ARTICLE
AU  - ANNE-LAURE RIVAL-TRINGALI
AU  - SYLVIE EUVRARD
AU  - EVELYNE DECULLIER
AU  - ALAIN CLAUDY
AU  - MICHEL FAURE
AU  - JEAN KANITAKIS
TI  - Conversion from Calcineurin Inhibitors to Sirolimus Reduces Vascularization and Thickness of Post-transplant Cutaneous Squamous Cell Carcinomas
DP  - 2009 Jun 01
TA  - Anticancer Research
PG  - 1927--1932
VI  - 29
IP  - 6
4099  - http://ar.iiarjournals.org/content/29/6/1927.short
4100  - http://ar.iiarjournals.org/content/29/6/1927.full
SO  - Anticancer Res2009 Jun 01; 29
AB  - Background: Immunosuppression favors the development of skin cancer. Experimental data suggest that sirolimus (SRL) has antitumoral and antiangiogenic properties. An investigation was undertaken into the effects of SRL on squamous cell carcinoma (SCC) developing in organ transplant recipients (OTR) receiving immunosuppressive treatments, with special emphasis on vascularization. Materials and Methods: SCC that developed in eight OTR before and after conversion from calcineurin inhibitors (CNI) to SRL were compared for thickness, differentiation, ulceration, perineural invasion, density of peritumoral infiltrate, peritumoral vascularization, density of T-regulatory cells and of intratumoral Langerhans cells and growth fraction. Results: SCC developing under SRL showed lower peritumoral vascularization and thickness, and higher growth fraction and density of peritumoral T-regulatory cells. Conclusion: Conversion from CNI to SRL at clinically relevant doses is associated in vivo with a reduced vascularization and thickness of post-transplant human cutaneous SCC. This effect could account for the beneficial effect of SRL on immunosuppression-induced skin carcinogenesis in humans.