%0 Journal Article %A CHISA NAGAKURA %A KATSUHIRO HAYASHI %A MING ZHAO %A KENSUKE YAMAUCHI %A NORIO YAMAMOTO %A HIROYUKI TSUCHIYA %A KATSURO TOMITA %A MICHAEL BOUVET %A ROBERT M. HOFFMAN %T Efficacy of a Genetically-modified Salmonella typhimurium in an Orthotopic Human Pancreatic Cancer in Nude Mice %D 2009 %J Anticancer Research %P 1873-1878 %V 29 %N 6 %X We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires the amino acids arginine and leucine. These mutations preclude growth in normal tissue but do not reduce bacterial virulence in tumor cells. The tumor-targeting strain of S. typhimurium, termed A1-R and expressing green fluorescent protein (GFP), was administered to an orthotopic human pancreatic tumor expressing red fluorescent protein (RFP) in nude mice. After 7 days of treatment, the pancreatic cancer had regressed without the need of chemotherapy or any other treatment. This new strategy demonstrates the clinical potential of bacterial targeting for pancreatic cancer. %U https://ar.iiarjournals.org/content/anticanres/29/6/1873.full.pdf