RT Journal Article
SR Electronic
T1 Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1831
OP 1834
VO 29
IS 5
A1 TAKEDA, KEN
A1 OGAWA, YOSHIHIRO
A1 ARIGA, HISANORI
A1 KOTO, MASASHI
A1 SAKAYAUCHI, TORU
A1 FUJIMOTO, KEISUKE
A1 NARAZAKI, KAKUTARO
A1 MITSUYA, MASATOSHI
A1 TAKAI, YOSHIHIRO
A1 YAMADA, SHOGO
YR 2009
UL http://ar.iiarjournals.org/content/29/5/1831.abstract
AB Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6% . On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.