PT  - JOURNAL ARTICLE
AU  - TAKEDA, KEN
AU  - OGAWA, YOSHIHIRO
AU  - ARIGA, HISANORI
AU  - KOTO, MASASHI
AU  - SAKAYAUCHI, TORU
AU  - FUJIMOTO, KEISUKE
AU  - NARAZAKI, KAKUTARO
AU  - MITSUYA, MASATOSHI
AU  - TAKAI, YOSHIHIRO
AU  - YAMADA, SHOGO
TI  - Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer
DP  - 2009 May 01
TA  - Anticancer Research
PG  - 1831--1834
VI  - 29
IP  - 5
4099  - http://ar.iiarjournals.org/content/29/5/1831.short
4100  - http://ar.iiarjournals.org/content/29/5/1831.full
SO  - Anticancer Res2009 May 01; 29
AB  - Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6% . On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.