<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">TAKEDA, KEN</style></author><author><style face="normal" font="default" size="100%">OGAWA, YOSHIHIRO</style></author><author><style face="normal" font="default" size="100%">ARIGA, HISANORI</style></author><author><style face="normal" font="default" size="100%">KOTO, MASASHI</style></author><author><style face="normal" font="default" size="100%">SAKAYAUCHI, TORU</style></author><author><style face="normal" font="default" size="100%">FUJIMOTO, KEISUKE</style></author><author><style face="normal" font="default" size="100%">NARAZAKI, KAKUTARO</style></author><author><style face="normal" font="default" size="100%">MITSUYA, MASATOSHI</style></author><author><style face="normal" font="default" size="100%">TAKAI, YOSHIHIRO</style></author><author><style face="normal" font="default" size="100%">YAMADA, SHOGO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1831-1834</style></pages><volume><style face="normal" font="default" size="100%">29</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT); fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6% . On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.</style></abstract></record></records></xml>