RT Journal Article
SR Electronic
T1 Treatment of Patients with Unresectable Advanced Carcinoma of Biliary Tract - Chemotherapy and Surgical Resection
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1783
OP 1786
VO 29
IS 5
A1 MORISE, ZENICHI
A1 SUGIOKA, ATSUSHI
A1 TANAHASHI, YOSHINAO
A1 OKABE, YASUHIRO
A1 IKEDA, MASAHIRO
A1 KAGAWA, TADASHI
A1 TAKEURA, CHINATSU
YR 2009
UL http://ar.iiarjournals.org/content/29/5/1783.abstract
AB Background: The results of 12 consecutive patients with unresectable advanced biliary tract carcinoma treated with first line chemotherapy of S1/cisplatin, combined surgical resection and second line chemotherapy of gemcitabine are evaluated. Patients and Methods: Eight patients with intrahepatic cholangiocarcinoma, 1 with extrahepatic cholangiocarcinoma and 3 with gallbladder carcinoma were included in the study. All patients were treated with S1/cisplatin. Two of the patients underwent combined surgical resection before and 2 after therapy. Second line chemotherapy of gemcitabine was administerd in 6 patients. Results: MST of the patients was 14.9 months. With S1/cisplatin therapy, 6 patients had PR and 4 had SD. Two patients with surgical resection after the therapy survived more than 3 years. Second line chemotherapy of gemcitabine with moderate effects and mild adverse effects was well tolerable. Conclusion: S1/cisplatin showed considerable anti-cancerous effects. Employing surgical resection for patients with good response may lead to the chance of long-term survival.