RT Journal Article SR Electronic T1 Phase II Study of the Combination of Nedaplatin and Weekly Paclitaxel in Patients with Advanced Non-small Cell Lung Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1733 OP 1738 VO 29 IS 5 A1 TAKASHI HIROSE A1 TOMOHIDE SUGIYAMA A1 SOJIRO KUSUMOTO A1 TAKAO SHIRAI A1 MASANAO NAKASHIMA A1 TOSHIMITSU YAMAOKA A1 KENTARO OKUDA A1 KEIICHI OGURA A1 TSUKASA OHNISHI A1 TOHRU OHMORI A1 MITSURU ADACHI YR 2009 UL http://ar.iiarjournals.org/content/29/5/1733.abstract AB Background: To date, no phase II trial of nedaplatin and weekly paclitaxel in patients with advanced non-small cell lung cancer (NSCLC) has been published. The safety and efficacy of the combination of nedaplatin and weekly paclitaxel in patients with NSCLC was examined. Patients and Methods: Patients with previously untreated NSCLC, either stage IIIB with pleural effusion or stage IV, were eligible if they had a performance status of 0 to 2, were 75 years or younger and had adequate organ function. Patients were treated with nedaplatin (80 mg/m2 on day 1) and weekly paclitaxel (90 mg/m2 on days 1, 8 and 15). Results: From March 2005 through March 2008, 47 patients (31 men and 16 women; median age, 66 years; age range, 38 to 75 years) were enrolled. The overall response rate was 53.2% (95% confidence interval, 38.1% to 67.9%). The median survival time was 13 months (range, 1 to 36 months), the 1-year survival rate was 62% and the median time to disease progression was 5 months (range, 1 to 19 months). Grade 3 to 4 hematologic toxicities included neutropenia in 38.3% of patients, thrombocytopenia in 2.1% and anemia in 23.4% . Although frequent non-hematologic toxicities were nausea, hepatic dysfunction and peripheral neuropathy, all cases were of only mild to moderate severity. Although 1 patient had grade 3 pulmonary toxicity due to drug-induced pneumonia, this patient recovered after receiving steroid therapy. Conclusion: This combination chemotherapy is effective and well tolerated and is an acceptable therapeutic option for patients with untreated advanced NSCLC.