PT  - JOURNAL ARTICLE
AU  - OHNO, SATOSHI
AU  - DOHI, SATOSHI
AU  - OHNO, YUMIKO
AU  - KYO, SATORU
AU  - SUGIYAMA, HARUO
AU  - SUZUKI, NOBUTAKA
AU  - INOUE, MASAKI
TI  - Immunohistochemical Detection of WT1 Protein in Endometrial Cancer
DP  - 2009 May 01
TA  - Anticancer Research
PG  - 1691--1695
VI  - 29
IP  - 5
4099  - http://ar.iiarjournals.org/content/29/5/1691.short
4100  - http://ar.iiarjournals.org/content/29/5/1691.full
SO  - Anticancer Res2009 May 01; 29
AB  - Background: The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer. Patients and Methods: A series of 70 endometrial cancer patients who had undergone a curative resection was studied to determine the correlation between WT1 expression, clinicopathological characteristics and prognosis. Tissue specimens were evaluated for WT1 expression by immunohistochemistry. Results: The expression of WT1 was strong in 31 patients (44%) and weak in 39 patients (56%). WT1 overexpression was associated with advanced FIGO stage (p=0.0266), myometrial invasion (p=0.0477) and high-grade histological differentiation (p=0.0049). The expression level of WT1 was found to be a significant predictor of disease relapse in univariate analysis (p=0.0233), but not in multivariate analysis (p=0.4757). Conclusion: These results suggested that tumor-produced WT1 provided additional prognostic information in endometrial cancer patients.